兰索拉唑治疗以慢性咽炎为表现的胃食管反流病患者的临床效果

Clinical effect of lansoprazole in the treatment of patients with gastroesophageal reflux disease with manifestation of chronic pharyngitis

目的探讨兰索拉唑治疗以慢性咽炎为表现的胃食管反流病患者的临床效果。方法选取2019年5月至2020年1月来深圳市龙华区人民医院就诊的87例以慢性咽炎为表现的胃食管反流患者为研究对象,采用随机数字表法分为乙组(43例)和甲组(44例)。乙组以L-谷氨酰胺呱化酸钠颗粒、莫沙必利治疗为主,甲组在乙组基础上加兰索拉唑进行治疗,比较两组患者咽部炎症情况、症状积分和临床疗效。结果实施不同治疗干预后,甲组患者的咽部炎症治疗总效率高于乙组,差异有统计学意义(P<0.05)。甲组和乙组患者治疗前的症状积分比较,差异无统计学意义(P>0.05),治疗后甲组和乙组患者的症状积分均低于治疗前,且甲组治疗后症状积分低于乙组,差异均有统计学意义(P<0.05)。甲组患者治疗总有效率高于乙组,差异有统计学意义(P<0.05)。结论针对胃食管反流病(以慢性咽炎为表现)患者进行兰索拉唑治疗,可提高患者的临床疗效,明显缓解症状,改善咽部炎症。

Objective To investigate the clinical effect of lansoprazole in the treatment of patients with gastroesophageal reflux disease with manifestation of chronic pharyngitis.Methods A total of 87 cases of gastroesophageal reflux patients with manifestation of chronic pharyngitis who came to the People’s Hospital of Longhua District from May 2019 to January 2020 were selected as the research objects,and they were divided into group B(43 cases)and group A(44 cases)by random number table method.Group B was treated with L-glutamine sodium squamate granules and mosapride as the main treatment.Group A was treated with lansoprazole on the basis of group B.The pharyngeal inflammation,symptom score and therapeutic efficacy were compared between the two groups.Results After the implementation of different treatment interventions,the total efficiency of pharyngeal inflammation in group A was higher than that in group B,with statistically significant difference(P<0.05).There was no significant difference in symptom score between group A and group B before treatment(P>0.05).After treatment,the symptom scores in group A and group B were lower than those before treatment,and the symptom score in group A was after treatment was lower than that in group B,the differences were statistically significant(P<0.05).The total effective rate of treatment in group A was higher than that in group B,the difference was statistically significant(P<0.05).Conclusion Lansoprazole treatment for patients with gastroesophageal reflux disease(manifestation of chronic pharyngitis)can improve the clinical efficacy of patients,significantly relieve symptoms,and improve pharyngeal inflammation.