V-ATPase对肿瘤细胞糖酵解的影响

Impacts of V-ATPase on glycolysis of tumor cells

V-ATPase是一类特殊的膜转运蛋白,通过驱动质子转运以及参与信号转导调节细胞各种生理过程。V-ATPase在细胞中的主要功能及作用已有大量研究,而关于其激活或抑制对于细胞糖酵解的影响,以及在肿瘤细胞所起作用的相关材料比较零散。通过整理近年来关于V-ATPase以及肿瘤糖酵解等的相关文献发现,V-ATPase在肿瘤细胞发生、发展、转移等过程中起到了至关重要的作用。因此,总结V-ATPase的结构功能,以及其对细胞糖酵解的影响甚至在癌细胞中起的作用,有利于提高对于V-ATPase的进一步认识,并便于探索其在肿瘤治疗新方案,尤其靶向治疗研究中的作用。

V-ATPase is a sort of special membrane transporter,which regulates various physiological processes of cells by driving proton transport and participating in signal transduction.The key functions and effects of V-ATPase in cells have been researched extensively,while the related materials about its activation or inhibition on cell glycolysis and its effects in tumor cells are scattered.By sorting out the related literatures about V-ATPase and tumor glycolysis in recent years,it is discovered that V-ATPase plays a vital effect in the occurrence,development and metastasis of tumor cells.Therefore,summarizing the structure and function of V-ATPase,its impacts on cell glycolysis and even its effects in cancer cells will help to improve the further understanding of V-ATPase and investigate its effects in new tumor treatment programs,especially in targeted therapy resear ch.