社会支持联合健康干预对甲状腺癌患者癌因性疲乏及生活质量的影响

Effect of social support combined health intervention on cancer-related fatigue and quality of life in patients with thyroid cancer

目的探讨社会支持联合健康干预对甲状腺癌患者癌因性疲乏及生活质量的影响。方法根据干预方案的不同将200例甲状腺癌患者分为观察组和对照组,各100例,其中,对照组给予健康干预,观察组在对照组基础上给予社会支持。比较两组患者的癌症疲乏量表(CFS)、欧洲癌症研究与治疗组织生命质量评估问卷(EORTC QLQ-C30)、抑郁自评量表(SDS)、焦虑自评量表(SAS)的评分,以及总三碘甲状腺原氨酸(TT3)、总四碘甲状腺原氨酸(TT4)水平。结果干预后,观察组患者CFS中躯体、情感、认知维度的评分及总分均低于对照组患者,差异均有统计学意义(P﹤0.05)。干预后,观察组患者EORTC QLQ-C30量表中躯体功能、角色功能、情绪功能、认知功能和社会功能维度的评分均高于对照组患者,差异均有统计学意义(P﹤0.05)。干预后,观察组患者的SDS、SAS评分均低于对照组患者,差异均有统计学意义(P﹤0.05)。干预后,观察组患者的TT3、TT4水平均高于对照组患者,差异均有统计学意义(P﹤0.05)。结论社会支持联合健康干预可明显改善甲状腺癌患者的癌因性疲乏程度、生活质量及心理状况,值得临床推广应用。

Objective To explore the effect of social support combined health intervention on cancer-related fatigue and quality of life in patients with thyroid cancer.Method Two hundred cases of thyroid cancer patients divided into observation group(n=100,treated with health intervention+social support)and control group(n=100,health intervention).The scores of cancer-related fatigue scale(CFS),European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30),self-rating depression scale(SDS)and self-rating anxiety scale(SAS),the level of total triiodothyronine protamine(TT3)and the level of total tetraiodothyronine protamine(TT4)were compared between the two groups.Result After intervention,the scores of body dimension,emotion dimension,cognition dimension and total scores of CFS in the observation group were significantly lower than those in the control group(P<0.05).The scores of body function,role function,emotional function,cognitive function and social function of EORTC QLQC30 in the observation group were significantly higher than those in the control group(P<0.05).The scores of SDS and SAS in the observation group were significantly lower than those in the control group(P<0.05).The level of TT3 and TT4 in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Social support combined health intervention can significantly improve the cancer-related fatigue,quality of life and psychological status of patients with thyroid cancer.