他汀类药物致新发糖尿病的危险因素、病理机制及防治措施研究进展

Research Progress on the Risk Factors,Pathological Mechanisms and Precautions of Statins-induced New-onset Diabetes Mellitus

他汀类药物是一类3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂,目前已广泛应用于冠状动脉粥样硬化性心血管疾病的一级和二级预防。然而长期使用他汀类药物与新发糖尿病的风险具有相关性。研究表明他汀类药物可对胰腺β细胞、周围组织以及相关基因产生影响,进而导致新发糖尿病。本文对他汀类药物致新发糖尿病的危险因素、病理机制及防治措施等方面的研究进展进行综述,以期为该类药物的合理应用、患者的个体化治疗以及相关的基础研究提供参考。

Statins is a kind of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors,and have been widely used in primary and secondary prevention of coronary atherosclerotic cardiovascular diseases.However,the risk of new-onset diabetes mellitus is correlated with long-term use of statins.Recent research shows that statins can affect pancreaticβcells,surrounding tissues and related genes,and then lead to new-onset diabetes mellitus.In this paper,research progress on the risk factors,pathological mechanisms and precaution measures of new-onset diabetes mellitus caused by statins are reviewed to provide basis for the rational application of statins,individual treatment of patients and the related basic researches.