桥本甲状腺炎患者血清IL-17、IL-35与维生素D的相关性

The correlation between serum IL-17 and IL-35 and vitamin D in Hashimoto thyroiditis

目的探讨桥本甲状腺炎(HT)患者血清白细胞介素(IL)-17、IL-35与维生素D的相关性。方法选取152例HT患者(HT组),按甲状腺激素水平分为甲状腺功能正常组(51例)、亚临床甲状腺功能减退(简称甲减)组(50例)、临床甲减组(51例),以体检健康者50名作为正常对照组。检测所有对象血清游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)、25-羟基维生素D[25(OH)D]、IL-17和IL-35水平。采用Pearson相关分析评估各项指标之间的相关性。结果HT组血清25(OH)D、IL-35水平显著低于正常对照组(P<0.05),IL-17水平显著高于正常对照组(P<0.05)。与甲状腺功能正常组比较,临床甲减组血清25(OH)D水平显著降低(P<0.05),亚临床甲减组和临床甲减组维生素D缺乏率升高(P<0.05)。亚临床甲减组与临床甲减组之间血清25(OH)D水平差异无统计学意义(P>0.05)。Pearson相关分析结果显示,在调整年龄因素后,HT组血清25(OH)D水平与TSH、TPOAb、IL-17均呈负相关(r值分别为-0.320、-0.254、-0.339,P<0.05),与IL-35呈正相关(r=0.243,P<0.05),与FT_(3)、FT_(4)及TgAb均无相关性(r值分别为0.181、0.012、0.018,P>0.05)。结论HT患者血清维生素D水平明显不足,且与IL-17和IL-35有关,提示维生素D水平可能与HT的发病及严重程度有一定关系。

Objective To investigate the correlation between serum interleukin(IL)-17 and IL-35 and vitamin D in Hashimoto thyroiditis.Methods A total of 152 HT patients(HT group)were selected and divided into normal thyroid function group(51 cases),subclinical hypothyroidism group(50 cases)and clinical hypothyroidism group(51 cases)according to the thyroid hormone level.Fifty healthy persons were taken as normal control.Serum levels of free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),thyroid stimulating hormone(TSH),thyroid globulin antibody(TgAb),thyroid peroxidase antibody(TPOAb),25-hydroxyvitamin D[25(OH)D],IL-17 and IL-35 were detected in all subjects.Pearson correlation analysis was used to evaluate the correlation between various indicators.Results Serum 25(OH)D and IL-35 levels in HT group were significantly lower than those in the normal control group(P<0.05),while IL-17 level was significantly higher than that in the normal control group(P<0.05).Compared with the normal thyroid function group,the serum 25(OH)D level of the clinical hypothyroidism group was significantly reduced(P<0.05),and the vitamin D deficiency rate of the subclinical hypothyroidism group and clinical hypothyroidism group was increased(P<0.05).There was no significant difference in serum 25(OH)D between subclinical hypothyroidism group and clinical hypothyroidism group(P>0.05).Pearson correlation analysis showed that after adjustment of age,serum 25(OH)D level in the HT group was negatively correlated with TSH,TPOAb,and IL-17(r values were-0.320,-0.254,and-0.339,P<0.05),positively correlated with IL-35(r=0.243,P<0.05),but not related with FT_(3),FT_(4),or TgAb(r values were 0.181,0.012,0.018,P>0.05).Conclusion The serum vitamin D level of HT patients is obviously insufficient,which is correlated with IL-17 and IL-35,suggesting that vitamin D level may be related to the onset and severity of HT.