艾司西酞普兰与文拉法辛治疗老年焦虑症的临床疗效与安全性

Clinical efficacy and safety of escitalopram and venlafaxine in the treatment of senile anxiety

目的探究艾司西酞普兰与文拉法辛治疗老年焦虑症的临床疗效与安全性。方法选取2017年1月至2019年1月本院收治的86例老年焦虑症患者,按随机数字表法分为A组和B组,各43例。A组行艾司西酞普兰治疗,B组行文拉法辛治疗。比较两组临床疗效、HAMA评分及不良反应发生率。结果两组临床疗效比较差异无统计学意义。治疗前,两组HAMA评分比较差异无统计学意义。治疗后,两组HAMA评分均低于治疗前。A组治疗1、2、3周HAMA评分均低于B组,差异有统计学意义(P<0.05)。A组不良反应发生率低于B组,差异有统计学意义(P<0.05)。结论予以老年焦虑症患者艾司西酞普兰与文拉法辛治疗,疗效相当。但艾司西酞普兰药效发挥快,不良反应发生率低,安全性高,值得推广。

Objective To investigate the clinical efficacy and safety of escitalopram and venlafaxine in the treatment of senile anxiety.Methods From January 2017 to January 2019,86 patients with senile anxiety were enrolled in our hospital.According to the random number table,they were divided into group A and group B,with 43 cases in each group.The group A was treated with escitalopram and group B was treated with venlafaxine.The clinical efficacy,HAMA score and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in clinical efficacy between the two groups.Before treatment,there was no statistically significant difference in HAMA scores between the two groups.After treatment,the HAMA scores in both groups were lower than before treatment.The HAMA score of group A was lower than group B at 1,2,and 3 weeks after treatment,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in group A was lower than that in group B,and the difference was statistically significant(P<0.05).Conclusion Escitalopram and venlafaxine were treated with senile anxiety patients,and the effects were equivalent.However,escitalopram has fast effect,low incidence of adverse reactions,and high safety,which is worthy of promotion.