齐拉西酮肌内注射治疗急性精神分裂症患者的临床效果

Clinical effect of Ziprasidone Intramuscular Injection in the treatment of acute schizophrenia

目的研究齐拉西酮针剂对急性精神分裂症患者的临床效果。方法选取2017年12月~2019年12月营口市第四人民医院治疗的120位急性精神分裂症患者作为研究对象,按照随机数字表法分为对照组(60例)和研究组(60例)。对照组采用氟哌啶醇针剂进行治疗,研究组采用齐拉西酮针剂进行治疗。分别检测两组在治疗前和治疗72 h后的阳性与阴性症状量表评分(PANSS),临床总有效率和临床不良反应总发生率等指标。结果两组治疗后的PANSS评分总分、阳性因子评分、阴性因子评分及一般精神病理学因子评分均低于治疗前,差异有统计学意义(P<0.05);两组治疗前的PANSS评分总分、阳性因子评分、阴性因子评分及一般精神病理学因子评分的比较,差异无统计学意义(P>0.05);治疗后,研究组PANSS评分总分、阳性因子评分、阴性因子评分以及不良反应总发生率均低于对照组,差异有统计学意义(P<0.05);治疗后,两组一般精神病理学因子评分的比较,差异无统计学意义(P>0.05);研究组临床总有效率高于对照组,差异有统计学意义(P<0.05)。结论齐拉西酮针剂对急性精神分裂症患者的临床疗效较为明显且安全性较高,与氟哌啶醇针剂相比不良反应发生率较低,值得临床借鉴。

Objective To study the clinical effect of Ziprasidone intramuscular injection in the treatment of acute schizophrenia.Methods A total of 120 patients with acute schizophrenia admitted to the Fourth People's Hospital of Yingkou City from December 2017 to December 2019 were selected as the research subjects.According to the random number table method,they were divided into control group(60 cases)and research group(60 cases).The control group was treated with Haloperidol Injection,and the research group was treated with Ziprasidone Injection.The positive and negative symptom scale scores(PANSS),the total clinical effectiveness rate and the total incidence of clinical adverse reactions of the two groups before treatment and 72 hours after treatment were tested.Results The total score of PANSS,positive factor score,negative factor score and general psychopathological factor score of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The total score of PANSS,positive factor score,negative factor score and general psychopathological factor score before treatment between the two groups were compared,and the differences were not statistically significant(P>0.05).The total score of PANSS,positive factor score,negative factor score and the incidence of adverse reactions of the research group after treatment were all lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistical significance in the general psychopathological factor scores between the two groups after treatment(P>0.05).The total clinical effectiveness rate of the research group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Ziprasidone Injection has obvious clinical efficacy and high safety in patients with acute schizophrenia.Compared with Haloperidol Injection,the incidence of adverse reactions is lower,which is worthy of clinical reference.