A型肉毒毒素治疗化脓性汗腺炎的研究进展

Research Progress in Hidradenitis Suppurativa and Its Botulinum Toxin A Therapy

化脓性汗腺炎是一种病变首发于毛囊的慢性化脓性炎症,以反复发作的痛性结节、脓肿、窦道、瘢痕形成为主要特点。其发病机制与遗传、免疫、感染、内分泌、吸烟、肥胖等多种因素有关。以往,化脓性汗腺炎的治疗包括抗生素治疗、手术治疗、放射治疗、激光治疗等,但效果都不尽理想。近年来,相关报道显示A型肉毒毒素注射治疗化脓性汗腺炎具有较好的效果。本文就化脓性汗腺炎的发病机制、临床表现、诊断、传统治疗方法和A型肉毒毒素治疗的相关进展进行综述。

Hidradenitis suppurativa(HS)is a chronic suppurative inflammation first occurring in hair follicles.It is characterized by recurrent painful nodules,abscesses,sinus tract,and scar formation.Its pathogenesis is related to heredity,immunity,infection,endocrine,smoking,obesity and other factors.In the past,the treatments of HS include antibiotic treatment,surgery treatment,radiotherapy,laser treatment and so on,but the effect is not ideal.In recent years,cases of botulinum toxin type A injection for the treatment of HS worldwide have been reported with good results.In this paper,the pathogenesis,clinical manifestations,diagnosis,traditional treatment method and the progress of botulinum toxin type A treatment were reviewed.