RAAS系统在继发性高血压疾病中的应用进展

The Progress of Applications of Renin-Angiotensin-Aldosterone System in Secondary Hypertension

在人体体内分布最广泛的内分泌调节系统是肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosteron system,RAAS),该系统在内分泌调节环节中发挥着至关重要的作用。在内分泌系统中,可以通过RAAS来实现对人体体内血量流动和外周阻力的控制,并且还可以通过RAAS来进一步调节体内血压、水和电解质的平衡,确保人体环境能够保持在一个稳定的状态。组成RAAS的主要部分有肾素、血管紧张素和醛固酮。针对RAAS各个组成部分进行深入研究之后,发现在RAAS系统中的一些部分与嗜铬细胞瘤、副神经节瘤等继发性高血压疾病密切相关。通过检测RAAS的组分可以辅助诊断因RAAS系统失调所导致的多种疾病。本文将从RAAS组分的检测方法及其在继发性高血压中的临床应用进行综述。

The most widely distributed endocrine regulation system in the human body is the renin-angiotensin-aldosterone system(RAAS),which plays a vital role in the endocrine regulation.In the endocrine system,RAAS can be used to control the blood flow and peripheral resistance of the human body,also to further adjust the balance of blood pressure,water and electrolytes in the body to ensure that the human physiological environment can be maintained in a stable state.The main components of RAAS are renin,angiotensin and aldosterone.After in-depth study of the various components of RAAS,it was found that some parts of the RAAS system are closely related to secondary hypertensive diseases,such as pheochromocytoma/paraganglioma.The detection of RAAS components can assist in the diagnosis of various diseases caused by disorders of the RAAS system.This article will review the detection methods of RAAS components and their clinical applications in secondary hypertension.