黄芩汤论治吉非替尼不良反应探析

Application of Huangqin Decoction in Treating Gefitinib Side Effects

肺癌的基本病机为气机不利、津液布散失调,吉非替尼治疗肺癌效果良好,且对寒湿之肺腺癌、阳气不充之亚裔女性、无热毒之不吸烟者疗效更佳,可知吉非替尼中药性能为辛热,其治疗作用来自其辛热之性,不良反应也与辛热之性密切相关。吉非替尼不良反应泄泻、皮疹、皮肤瘙痒、脱屑的特点均表现为温邪伤及太阳少阳二经的症候,而黄芩汤针对的基本病机为太阳少阳合病,与吉非替尼一系列不良反应背后的病机相一致,基于此,可知以黄芩汤为主方能治疗吉非替尼不良反应。

The basic pathogenesis of cancer is disorder of qi movement and fluid. The gefitinib not only works well in the treatment of cancer, but also work better in following three aspects: lung adenocarcinoma with cold-dampness syndrome, Asian women with yang deficiency syndrome, Non-smoker with no heat-toxicity. So we learn from this fact that The gefitinib’s four nature of drugs is hot, the five flavours of The gefitinib is pungent, the curative effect and the side effects both come from Chinese herbal medicine property. We can attribute aolmost all of side effects to heat pathogen invading Taiyang and Shaoyang Channels. In Shanghan Lun, huangqin decoction is a model answer of concurrent disease of Taiyang and Shaoyang Channels. Based on this, we can draw a conclusion that huangqin decoction works well in treating gefitinib side effects.