免疫性血小板减少症患者肠道菌群宏基因组学研究进展

Research progress in metagenomics of intestinal microbiota in patients with immune thrombocytopenia

免疫性血小板减少症(ITP)是儿童时期临床最常见的获得性出血性疾病,其发病机制比较复杂。目前认为免疫异常是其发病的主要原因。而近年来肠道菌群在免疫调节自稳和免疫耐受中的作用已逐渐明确,并且其失衡在诸多免疫性疾病中起着关键的作用。因此研究肠道菌群失衡与ITP发病的关系,可以进一步通过恢复肠道菌群平衡作为防治ITP的一种新的策略。该文就ITP患者肠道菌群宏基因组学研究进展进行综述。

Immune thrombocytopenia(ITP)is the most common acquired hemorrhagic disorder during childhood,and the pathogenesis of the disease is complex.At present,immune abnormality is considered to be the main cause of the disease.In recent years,the role of intestinal microbiota in immunomodulatory homeostasis and immune tolerance has been gradually clarified,and its imbalance plays a key role in many immune diseases.Therefore,the study of the relationship between intestinal microbiota imbalance and the onset of ITP can further restore the balance of intestinal microbiota as a new strategy for the prevention and treatment of ITP.In this paper,the research progress in metagenomics of intestinal microbiota in ITP patients is reviewed.