摘要
丝裂原活化蛋白激酶(MAPKs)是细胞内信号传导的重要组成部分,p38丝裂原活化蛋白激酶(p38MAPK)是众多MAPK信号通路之一,调控病理性疼痛的发生和维持。近年来,对于p38MAPK信号通路的研究众多,本文拟对其分子结构和功能,信号通路的激活及其在病理性疼痛中作用机制的最新研究进展综述如下,以期为临床镇痛提供新的思路。
Mitogen activated protein kinases(MAPKs)are an important part of intracellular signal transduction.p38 mitogen activated kinase(p38MAPK)is one of the MAPK signaling pathways,which regulates the occurrence and maintenance of neuropathic pain.In recent years,there are many studies on p38MAPK signaling pathway.The molecular structure and function,activation of this signaling pathway and its mechanism in neuropathic pain are summarized in this review to provide new ideas for clinical analgesia.
作者
李霄
王彩霞
李敬宇
王莹
师文静
张沛
Li Xiao;Wang Caixia;Li Jingyu;Wang Ying;Shi Wenjing;Zhang Pei(Anesthesiology Student,Grade 2019,Inner Mongolia Medical University,Hohhot City,Inner Mongolia Autonomous Region 010110,China;Department of Anesthesiology,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot City,Inner Mongolia Autonomous Region 010030,China;Department of Cervical Spine Surgery,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot City,Inner Mongolia Autonomous Region 010030,China)
出处
《中华疼痛学杂志》
2021年第1期103-109,共7页
Chinese Journal Of Painology
