四川省儿童艾滋病病例特征分析

Characteristics of reported HIV infections in children in Sichuan province

目的了解四川省报告0~14岁艾滋病病毒(HIV)感染者特征,为制定儿童随访管理干预方案提供有效信息。方法通过"中国艾滋病综合防治信息系统"获得截至2017年底四川省经确认检测年龄在0~14岁间HIV感染儿童流行病学特征、CD4^(+)T淋巴细胞(简称CD4细胞)检测结果、死亡及治疗情况,并分析其历年来变化趋势。结果截至2017年底,四川省累计发现0~14岁儿童HIV感染者1909例,确诊平均年龄(5.24±3.45)岁,母婴传播确诊平均年龄(4.49±2.96)岁。确诊儿童中3~9岁占57.6%(1099例),男童占58.3%(1113例),彝族占77.2%(1474例),母婴传播占78.7%(1502例)。91.8%(1752例)进行CD4细胞检测,首次CD4细胞检测时间在3个月内占60.1%(1053例),2006年以前至2017年,治疗比例从85.7%上升到98.1%,死亡比例从58.8%下降到11.1%,晚发现比例(首次CD4细胞计数<200个/μL)从35.0%下降到13.4%。结论四川省儿童艾滋病治疗比例上升,死亡及晚发现比例下降,但随着工作的全面开展,检测力度上升,发现病例数呈增长趋势。

Objective To understand the epidemiological characteristics of reported HIV-infected children(aged 0-14)in Sichuan province,and to provide effective reference for development of an intervention plan for follow-up and management of the children.Methods Data of HIV-infected children between the ages of 0-14 years with confirmation test by the end of 2017 were obtained through the"China Integrated AIDS Information System".The information of their epidemiological characteristics,CD4^(+)T lympho cytes(CD4 cells)test results,death and treatment status were collected and analyzed for the trend of changes over the years.Results By the end of 2017,a total of 1909 HIV/AIDS infected children had been confirmed.The average age at diagnosis was 5.24±3.45 years,and the average age at diagnosis of mother-to-child transmission was 4.49±2.96 years.The confirmed cases were mainly of younger age groups(3-9 years old),accounting for 49.5%(1099 cases),boys 58.3%(1113 cases),Yi people 77.2%(1474 cases),and mother-to-child transmission 78.7%(1502 cases).91.8%(1752 cases)had CD4 test,and 60.1%(1053 cases)received the first CD4 cell detection within 3 months.Between 2006 and 2017,the rate of treatment increased from 85.7%to 98.1%,the rate of death decreased from 58.8%to 11.1%,and the rate of late detection(initial CD4 cell count<200/μL)decreased from 35.0%to 13.4%.Conclusion The proportion of HIV/AIDS treatment among children in Sichuan is on the rise,and death and late detection in decline.However,with the comprehensive development of the HIV/AIDS prevention and control,the number of HIV detection is increasing,and the detected number of HIV/AIDS among children is also increasing.