摘要
帕金森病中轴症状如步态障碍和平衡障碍对抗帕金森药物及脑深部电刺激反应不佳,有报道称脊髓电刺激对其有一定的改善作用,但效果尚不一致。本文对脊髓电刺激用于治疗帕金森病的动物实验及临床研究进行综述,以期探索脊髓电刺激的作用机制及对未来研究和临床应用提供依据。
Axial symptoms of Parkinson's disease,such as gait disturbance and postural instability,do not respond well to anti-Parkinson drugs or deep brain stimulation.It has been reported that spinal cord stimulation can improve these symptoms,but the effects are not consistent.This article reviews animal experiments and clinical trials on spinal cord stimulation in the treatment of Parkinson's disease,in order to explore the mechanisms of action of spinal cord stimulation and give some suggestions for future research and clinical application.
作者
马琳
陈彪
Ma Lin;Chen Biao(Department of Neurobiology,Neurology and Geriatrics,Xuanwu Hospital of Capital Medical University,Beijing Institute of Geriatrics,Beijing 100053,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2021年第1期128-131,共4页
Chinese Journal of Geriatrics
基金
国家重点研发计划(2018YFC1312001,2017YFC0840105,2017ZX09304018)
北京市科学技术委员会(Z171100000117013)。
关键词
帕金森病
电刺激
Parkinson disease
Electric stimulation
