间充质干细胞成骨和成脂分化调控机制研究

Regulation mechanism of osteogenic differentiation and adipogenic differentiation in mesenchymal stem cells

间充质干细胞(MSCs)是人体内参与免疫平衡、维持组织器官的稳态和功能以及组织损伤修复的一类重要成体干细胞。MSCs具有自我更新能力和多向分化潜能,国际干细胞协会将MSCs向脂肪、成骨等细胞分化的能力作为其重要的检测标准。作为骨细胞和脂肪细胞的共同来源,MSCs在成骨和成脂分化之间相互协调和相互竞争,并在多种调控因素作用下保持着微妙的平衡。对MSCs成骨、成脂分化的信号通路、调控因素进行分析,并对其分化诱导方法以及鉴定方法进行总结,以期为MSCs基础研究及临床应用提供参考依据。

Mesenchymal stem cells(MSCs)are an important adult stem cells,which participate in immune balance,maintain the homeostasis and function of tissues and organs,and repair damaged tissues.Mesenchymal stem cells have the self-renewal and multi-differentiation potential,able to differentiating into multiple cell types,such as bone,fat and other cells.International Stem Cell Association regards the ability as an important standard of MSCs.As common progenitor cells of osteoblasts and adipocytes,MSCs delicately balanced their differentiation commitment.This review analyzes the signaling pathways and regulatory factors of MSCs osteogenic and adipogenic differentiation.The Induced differentiation methods and identification methods are also summarized,so as to provide reference for basic research and clinical application of MSCs.