阴道用乳杆菌活菌胶囊联合妇阴康洗剂治疗混合性阴道炎的疗效观察

Clinical observation of Live Lactobacillus Capsule for vaginal combined with Fuyinkang Lotion in treatment of mixed vaginitis

目的研究阴道用乳杆菌活菌胶囊联合妇阴康洗剂治疗混合性阴道炎患者的疗效及对阴道菌群的影响。方法选取2018年6月—2019年6月北京市丰台区妇幼保健院诊治的混合性阴道炎患者112例作为研究对象,将所有患者随机分为对照组(n=56)与观察组(n=56)。对照组患者给予阴道用乳杆菌活菌胶囊,每晚患者用温清水将外阴部清洗后擦干,将双手洗净,仰卧,食指戴内含一次性无菌手指套,取出1粒放置于阴道深处,1粒/次,1次/d。观察组在对照组治疗的基础上给予妇阴康洗剂治疗,用温清水将外阴部清洗后擦干,患者仰卧,取10 mL洗剂注入阴道内,将液体在阴道内维持20 min,防止药液外流,每晚1次。10 d为1个疗程。两组均治疗2个疗程。观察两组患者的临床疗效、复发率,对比两组的阴道pH值、清洁度、阴道菌群分布和症状改善时间。结果治疗后,对照组和观察组的总有效率分别为83.93%、96.43%,复发率分别为26.79%和3.57%,两组临床疗效和复发率比较差异有统计学意义(P<0.05)。治疗后,两组患者阴道pH值低于治疗前(P<0.05);治疗后,观察组阴道pH值、清洁度III度显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者检出乳杆菌高于治疗前,酵母菌、肠杆菌、葡萄球菌检出个数低于治疗前(P<0.05);治疗后,观察组乳杆菌高于对照组,且酵母菌、肠杆菌、葡萄球菌检出个数低于对照组(P<0.05)。治疗后,观察组白带增多、异味、外阴瘙痒、阴道灼痛症状改善时间显著短于对照组,差异有统计学意义(P<0.05)。结论阴道用乳杆菌活菌胶囊联合妇阴康洗剂治疗混合性阴道炎患者具有显著疗效,并可恢复阴道菌群平衡。

Objective To study the efficacy of Live Lactobacillus Capsule for vaginal combined with Fuyinkang Lotion in treatment of mixed vaginitis and its influence on vaginal microflora.Methods A total of 112 patients with mixed vaginitis treated in Fengtai District Maternal&Child Health Hospital from June 2018 to June 2019 were selected as the research objects,and all the patients were randomly divided into the control group(n=56)and the observation group(n=56).Patients in the control group were given Live Lactobacillus Capsule for vaginal,patients washed genitals with warm water and dried every night,wore disposable sterile finger sleeve with index finger,took out one capsule and placed it deep in the vagina,one capsule per time,and once daily.Patients in the observation group were treated with Fuyinkang Lotion on the basis of control group,took 10 mL lotion and inject it into the vagina.Keep the liquid in the vagina for 20 min to prevent the outflow of the liquid,once a night.10 days as one course of treatment.Both groups received 2 courses of treatment.The clinical efficacy and recurrence rate of two groups were observed,and the vaginal pH value,cleanliness,distribution of vaginal microflora,and symptom improvement time of two groups were compared.Results After treatment,the total effective rates of the control group and the observation group were 83.93%and 96.43%,respectively,and the recurrence rates were 26.79%and 3.57%,respectively.There were statistically significant differences in the clinical efficacy and recurrence rates between two groups(P<0.05).After treatment,the pH value of vagina was lower than that before treatment(P<0.05).After treatment,pH value and cleanliness III of the vagina in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the number of lactobacillus detected in two groups was higher than that before treatment,and the number of yeast,enterobacteria,and staphylococcus detected in two groups was lower than that before treatment(P<0.05).After treatment,the number of lactobacillus in the observation group was higher than that in the control group,and the number of yeast,enterobacter,and staphylococcus in the observation group was lower than that in the control group(P<0.05).After treatment,the improvement time of increased leucorrhea,peculiar smell,vulva pruritus,and vaginal burning symptoms in the observation group was significantly lower than that in the control group,with statistically significant differences(P<0.05).Conclusion Live Lactobacillus Capsule for vaginal combined with Fuyinkang Lotion in treatment of mixed vaginitis has a significant effect,and can restore the balance of vaginal flora.