当归六黄汤的药理作用和临床应用研究进展

Advance on Pharmacological Effect and Clinical Application of Danggui Liuhuang Tang

当归六黄汤作为中国传统经典名方之一,自金元以来被各大医学名家运用于临床。本文通过对当归六黄汤相关文献进行查阅及梳理,发现其具有广泛的药理活性,主要通过抑制肿瘤坏死因子、白细胞介素等炎症因子的产生和相关通路的激活等途径发挥抗炎及抗胰岛素抵抗作用,并通过多成分、多靶点、多途径减弱炎症信号以及细胞外基质聚集,达到抗肝纤维化的作用。此外,关于当归六黄汤在呼吸系统方面的研究也有涉及,但对其机制并未进行深入探索。当归六黄汤在临床上常被用于治疗各种汗证,且在治疗甲状腺疾病、糖尿病、呼吸道等疾病上有明显疗效。故对其近年的药理作用研究以及临床实践应用进行综述,为当归六黄汤后续发展提供具有价值性的线索。

Danggui Liuhuang Tang,as one of classical traditional Chinese medicine prescriptions,has been used by major medical experts in clinic since Jin and Yuan dynasties. After review and summarization of relevant literatures on the pharmacological effects and clinical application of Danggui Liuhuang Tang,it was found that Danggui Liuhuang Tang has a wide range of pharmacological activities, and exerts its antiinflammatory and anti-insulin resistance effects mainly by inhibiting the production of inflammatory factors,such as tumor necrosis factor and interleukin and activating related pathways. In addition,Danggui Liuhuang Tang inhibits the occurrence and development of hepatic fibrosis by attenuating proinflammatory signaling and extracellular matrix accumulation with multiple components,multiple targets,and multiple pathways. Danggui Liuhuang Tang has been widely used in sweat syndromes,with an obvious effect in the treatment of thyroid diseases,diabetes,respiratory tract and other diseases. This paper reviews and summarizes the pharmacological effects and clinical application of Danggui Liuhuang Tang,in an attempt to provide some valuable clues for the subsequent development of Danggui Liuhuang Tang.