胞外体来源的非编码RNA在颅脑创伤中的作用

Effect of exosome-derived non-coding RNA on traumatic brain injury

颅脑创伤是世界范围内死亡和致残的主要原因,给公共健康带来了巨大的威胁,但目前的诊断和治疗手段十分有限。胞外体是介导细胞间通信和物质转运的微囊泡,其中包含了丰富的非编码RNA。它们参与颅脑创伤后的病理生理反应过程,但具体的作用机制仍不明确。作为胞外体内容物的重要组成部分,非编码RNA对研究颅脑创伤的诊断、精准治疗、疗效评估、预后预测及并发症的防治等均具有重要意义。

Traumatic brain injury(TBI)is a main cause of death and disability worldwide,posing a serious threat to public health.But currently,the diagnosis and treatments for TBI are still very limited.Exosomes are a group of extracellular vesicles and participate in multiple physiological processes including intercellular communication and substance transport.Non-coding RNAs(ncRNA)are of great abundancy as cargo of exosomes.Previous studies have shown that ncRNAs are involved in several pathophysiological processes of TBI.However,the concrete mechanisms involved in the effects induced by exosome-derived ncRNA remain largely unknown.As an important component of exosomes,ncRNA is of great significance for diagnosis,precise treatment,response evaluation,prognosis prediction,and complication management after TBI.