姜黄素在鼻咽癌放疗中抗癌机制的研究进展

Research progress on anticancer mechanism of Curcumin in radiotherapy for nasopharyngeal carcinoma

放疗作为鼻咽癌治疗的首选方案一直是研究关注点,放疗作为局部性治疗手段,其疗效的提高受到多种因素的影响。放疗导致的肿瘤微环境改变促使癌细胞产生放疗抗拒,严重影响了治疗效果。姜黄素是一类具有抗肿瘤作用的天然植物提取物,能够从多个环节干预肿瘤的发生发展,具有促进细胞凋亡、阻断细胞周期、抗炎、抗转移及免疫调节等多种药理功能。近年来,免疫治疗因其靶向性高、副作用小而被临床肿瘤治疗广泛关注,尤其表现在通过调控先天性和后天性免疫细胞功能表型来增强放射治疗的功效。姜黄素的免疫调节功能可以极大地改善肿瘤微环境从而极大地提升了放射疗效。本文就姜黄素作用于肿瘤发生发展的研究进展及与增加肿瘤放疗敏感性的关联进行综述。

Radiotherapy as the first choice of nasopharyngeal carcinoma treatment has been the focus of research.Radiotherapy is ofter considered as a local therapy and the improvement of its efficacy is affected by multiple factors.Cancer cells resistance to radiotherapy induced alternation of tumor microenvironment seriously affects the effectiveness of cancer treatment.Curcumin is a kind of natural plant extract with anti-tumor effect,which can interfere with the process of tumorigenesis and development from many aspects.Curcumin has many pharmacological functions,such as promoting cell apoptosis,blocking cell cycle,anti-inflammation,anti-metastasis,immunomodulation and so on.Recently,immunotherapy is widely investigated in clinical cancer treatment due to its highly targeting property and mild side effect,especially through modulating the functional phenotype of innate and adaptive immune cell to augment radiotherapy efficacy.The immunomodulatory effect of Curcumin can ameliorate the tumor microenvironment,which greatly improves the efficacy of radiotherapy.In this review,the research progress of Curcumin on tumorigenesis and development and its association with tumor radiation resistance are summarized as follows.