羟甲基纤维素钠眼液联合人工泪液治疗白内障超声乳化术后干眼症的临床效果

Clinical effect of Carboxymethyl Cellulose Sodium Eye Drops combined with artificial tears in the treatment of dry eye after phacoemulsification of cataract

目的探讨羟甲基纤维素钠眼液联合人工泪液治疗白内障超声乳化术后干眼症的临床效果。方法选取2018年1月~2019年1月景德镇市第一人民医院收治的300例白内障超声乳化术后干眼症患者作为研究对象,根据抽签法随机分为三组,对照a组、对照b组、观察c组,每组各100例(100眼)。对照a组在术前使用0.5%左氧氟沙星眼液,术后早期(2周)使用妥布霉素地塞米松眼液,在此基础上,对照b组在术后加用羧甲基纤维素钠眼液,观察c组在术前及术后均加用人工泪液和羧甲基纤维素钠眼液。比较三组的干眼症状评分、角膜荧光染色评分、泪膜破裂时间(BUT)评分及治疗效果。结果观察c组、对照b组术后3个月干眼症状评分及角膜荧光染色评分低于术后7 d,BUT评分高于术后7 d,且观察c组、对照b组术后7 d、术后1个月、术后3个月干眼症状评分及角膜荧光染色评分均低于对照a组,BUT评分高于对照a组,差异有统计学意义(P<0.05)。观察c组、对照b组患者的治疗总有效率均高于对照a组,且观察组c组总有效率高于对照b组,差异有统计学意义(P<0.05)。结论在白内障超声乳化术后实施羟甲基纤维素钠眼液联合人工泪液治疗,治疗效果显著,且安全性较高,值得研究和推广。

Objective To investigate the clinical effect of Carboxymethyl Cellulose Sodium Eye Drops combined with artificial tears in the treatment of dry eye after phacoemulsification of cataract.Methods A total of 300 cataract patients with dry eyes after phacoemulsification in Jingdezhen No.1 People's Hospital from January 2018 to January 2019 were selected as the research subjects.According to the drawing lottery method,they were divided into three groups,control group a,control group b,and observation group c,with 100 cases(100 eyes)in each group.Control group a was treated with 0.5%Levofloxacin Eye Drops before surgery,and Tobramycin and Dexamethasone Eye Drops early after surgery(2 weeks).On this basis,control group b was treated with Carboxymethyl Cellulose Sodium Eye Drops after surgery,and observation group c was treated with artificial tears and Carboxymethyl Cellulose Sodium Eye Drops before and after surgery.Dry eye symptom score,corneal fluorescence staining score,tear break-up time(BUT)score and treatment effect of the three groups were compared.Results The dry eye symptom score and corneal fluorescence staining score of observation group c and control group b at three months after surgery were lower than those at 7 d after surgery,and the BUT score was higher than that at 7 d after operation,the dry eye symptom scores and corneal fluorescence staining scores of observation group c and control group b at 7 d,1 month,and 3 months after surgery were lower than those of control group a,while BUT score was higher than that of control group a,and the differences were statistically significant(P<0.05).The total effective rate of observation group c and control group b was higher than that of control group a,and the total effective rate of observation group c was higher than control group b,the differences were statistically significant(P<0.05).Conclusion The application of Carboxymethyl Cellulose Sodium Eye Drops and artificial tears after phacoemulsification of cataracts has remarkable therapeutic effects with high safety.It is worthy of exploration and promotion.