Suzuki偶联反应合成沙坦联苯研究进展

Progress on Synthesis of Sartanbiphenyl via Suzuki Coupling Reactions

沙坦联苯,即2-氰基-4′-甲基联苯,是抗高血压药物沙坦类药物的关键中间体。通过对沙坦联苯的结构进行衍生和修饰,可得到大多数沙坦类药物。因此,沙坦联苯的合成方法一直是有机合成化学家关注的热点研究领域。Suzuki偶联反应是合成沙坦联苯最重要的方法之一。近二十年来,文献中出现了大量利用Suzuki偶联反应合成沙坦联苯的催化体系。根据原料的不同,从不同卤代芳烃角度对沙坦联苯的合成方法进行了综述,旨在掌握目前利用Suzuki偶联反应合成沙坦联苯的现状,以期对同行工作者有所启发和帮助。

Sartanbiphenyl,namely 2-cyano-4′-methylbiphenyl,is the key intermediate for antihypertensive sartan drugs.Most sartan drugs could be prepared by the derivations and modifications of sartanbiphenyl.Therefore,the synthesis of sartanbiphenyl is always being a hot topic for the organic synthetic chemists.Suzuki coupling reaction is one of the most important synthetic methods for sartanbiphenyl and lots of catalytic systems have been reported in literatures in recent twenty years.This work should be helpful for the researchers of sartanbiphenyl,reviewed the synthetic methods of sartanbiphenyl via Suzuki coupling reaction based on the raw materials used.