GP方案治疗局部晚期鼻咽癌患者的急性不良反应及预后Meta分析

Acute Adverse Effects and Prognosis of Locally Advanced Nasopharyngeal Carcinoma Patients Treated with GP Regimen:A Meta-analysis

目的比较吉西他滨联合铂类(GP)方案与其他含铂化疗方案治疗鼻咽癌的不良反应与预后。方法检索相关数据库并纳入GP方案对比其他化疗方案治疗局部晚期鼻咽癌的相关研究。对纳入文献进行方法学评估,使用RevMan5.3和Stata15软件工具进行统计学分析。结果GP方案重度白细胞下降及消化道反应相对较轻(P<0.05),而重度肝功能损伤及重度血小板下降较其他方案严重(P<0.05)。GP方案治疗的患者无远处转移生存率更高(P=0.004)。结论GP方案安全、经济,且更能控制远处转移,可作为局部晚期鼻咽癌诱导化疗方案之一。

Objective To compare the adverse effects and prognosis of locally advanced nasopharyngeal carcinoma(LANC)patients between the gemcitabine combined platinum(GP)regimen and other platinum-containing chemotherapy regimens by meta-analysis.Methods We searched relevant databases and included the studies about comparing GP and other chemotherapy regimens in the treatment of LANC.Methodological quality was assessed for each included study.Statistical analysis was carried out using RevMan5.3 and Stata15 software.Results The patients on GP regimen had a lower incidence of severe leukopenia and severe gastrointestinal reaction but a higher incidence of severe thrombocytopenia and hepatoxicity than those on other regimens(P<0.05).The patients on GP regimen had a higher distant metastasis-free survival(P=0.004).Conclusion GP regimen can be used as a safe,alternative and economical induction chemotherapy regimen for locally advanced nasopharyngeal carcinoma.