TP53家族基因TP73与肿瘤发生的研究进展

Progress of TP53 Family Gene TP73 and Tumorigenesis

p73蛋白是p53蛋白家族的主要成员之一,其编码基因TP73与TP53基因高度同源。与p53蛋白类似,p73蛋白功能涉及细胞生命活动的各个方面;但又与p53不同,p73蛋白在机体正常的细胞活动和肿瘤的发生发展中不仅扮演着抑癌因子的角色,其功能的复杂性和重要性丝毫不亚于p53蛋白。肿瘤发生涉及多种细胞生物学过程,例如细胞凋亡、自噬、迁移和代谢等。这些正常的细胞生物学过程受多条细胞信号通路的严密调节而维持机体稳态,一旦调节通路发生致癌性异常将最终导致肿瘤发生。因此,本文主要聚焦在近几年p73与肿瘤发生的重要研究成果及其异于p53蛋白的独特功能。

P73 protein is one of the main members of p53 protein family,and its coding gene TP73 is highly homologous to TP53 gene.On one hand,similar to p53,p73 protein is involved in all aspects of cell life.On the other hand,unlike the p53,not only p73 protein plays the role of tumor suppressor in normal cell activities and tumor development,but also the function of p73 protein is no less complex and important than that of p53 protein.Tumorigenesis involves a variety of cellular biological processes,such as apoptosis,autophagy,cell migration and cell metabolism.These normal cellular biological processes are tightly regulated by multiple cellular signaling pathways to maintain homeostasis.Once a carcinogenic abnormality occurs,it will eventually lead to tumorigenesis.Therefore,this paper mainly focuses on the important research results of p73 and tumorigenesis and its unique function different from p53 protein in recent years.