摘要
在过去的10年中,以新德里金属β-内酰胺酶-1(NDM-1)为代表的金属β-内酰胺酶在全球范围内广泛传播,对公共卫生安全产生了较大的威胁。尤其是近些年这些酶的突变体的出现使得耐药菌给人类健康造成了更加复杂和困难的挑战。目前,临床上仍然缺乏有效的治疗药物和手段。研发有效广谱的抑制剂成为解决此问题的重点。因此本文将针对NDM-1及其相关抑制剂复合物的三维结构解析工作进行综述,希望从生物学机制研究的角度带给相关研究人员一点启发和帮助。
In the past decade,metallo-β-lactamases,represented by New Delhi metallo-β-lactamases(NDM-1),have been widely spread around the world,threatening public health and safety.Especially in recent years,the emergence of mutants of these enzymes has caused more complex and difficult challenges to human health.At present,there is still a lack of effective treatment drugs and means.The key to solve this problem is to develop effective broad-spectrum inhibitors of the enzyme.Therefore,we review the three-dimensional structure analysis of NDM-1 and its related inhibitor complexes,to give some inspiration and to help relevant researchers from the perspective of biological mechanism research.
作者
崔灿
杨海涛
王泽方
Can Cui;Haitao Yang;Zefang Wang(Experimental Center of Structural Biology,School of Life Sciences,Tianjin University,Tianjin 300072,China;Shanghai Institute for Advanced Immunochemical Studies,School of Life Science and Technology,Shanghai Tech University,Shanghai 201210,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2021年第1期41-57,共17页
Acta Microbiologica Sinica
基金
国家自然科学基金(31970048,81601593)。