胎儿同种免疫性血小板减少症的产科管理进展

Obstetrical management of fetal alloimmune thrombocytopenia

胎儿同种免疫性血小板减少症(fetal alloimmune thrombocytopenia,FAIT)是一种围产期的严重并发症,影响胎儿发育,甚至导致胎儿宫内出血及死亡。虽然FAIT危害严重,但因发病率低、治疗经验有限,临床诊治存在较多争议。本文基于国内外指南、共识及相关研究对FAIT的发病概况、高危因素筛查、产前管理流程、分娩管理等问题进行综述,期望为FAIT的临床管理提供帮助。

Fetal alloimmune thrombocytopenia(FAIT)is a severe perinatal complication,which can seriously affect fetal development,and may even lead to intrauterine hemorrhage and intrauterine death.There are controversies in the clinical diagnosis and treatment of the disease due to its low incidence and limited treatment experience.This paper reviews the progress to date in understanding the condition,incidence,screening of high-risk factors,prenatal and delivery management of FAIT based on domestic and foreign guidelines,in order to help obstetricians in the clinical management of FAIT.