北京市海淀区孕妇膳食频率与头发中邻苯二甲酸酯水平的关联研究

Association between food frequency and hair concentration of phthalates among pregnant women in Haidian District,Beijing

目的分析北京市海淀区孕妇头发样本中邻苯二甲酸酯(PAEs)水平,探讨膳食频率与PAEs污染物水平的关联。方法本研究依托于北京大学生育健康研究所与海淀妇幼保健院开展的孕期队列项目,从北京市海淀区妇幼保健院自2017年10月至2018年10月期间募集的孕妇人群中随机挑选152例具有头发样本的孕妇,使用三重四极杆气相色谱-质谱联用仪测定头发中9种PAEs浓度。本研究使用的问卷为队列募集时已有的问卷,通过问卷调查获得孕妇的社会人口学信息与膳食频率特征。结果研究人群头发中9种PAEs均有不同程度的检出(检出率55.9%~98.0%),其中邻苯二甲酸二(2-乙基己基)酯(DEHP)浓度最高,浓度中位数(四分位数)为1837.5(641.7,4473.3)ρg/mg。孕妇近期蛋奶类食品摄入与头发中较低水平的邻苯二甲酸二壬酯(DNP)存在显著关联,调整比值比为0.29(95%CI:0.12~0.66)。结论北京市海淀区孕妇头发中PAEs处于较低水平,本研究发现多种膳食摄入与特定PAEs暴露存在关联,食用蛋奶类食物可能是降低PAEs暴露的保护因素。

Objective To describe the hair concentrations of phthalates(PAEs)and investigate their associations with the dietary habit among pregnant women in Haidian District,Beijing.Methods Our study was based on a pregnant cohort established by the Institute of Reproductive and Child Health,Peking University and Beijing Haidian Maternal and Child Health Hospital.A total of 152 pregnant women with available hair samples in the cohort were randomly selected in our study from October 2017 to October 2018.The concentrations of 9 PAEs were analysed using gas chromatography-triple quadrupole mass spectrometry.The questionnaires were used to assess the information of social characteristics and dietary habit of pregnant women.Results All PAEs were detected in hair samples with detection range of 55.9%-98.0%.Among all the concerned PAEs,DEHP has its highest detection rate and concentration in hair sample with a median(interquartile range)of 1837.5(641.7,4473.3)ρg/mg.Egg and milk intake were significantly associated with lower hair concentration of DNP with adjusted odds ratio of 0.29(95%CI:0.12-0.66).Conclusion The exposure level of PAEs was relatively low among pregnant women in Haidian District,Beijing.Diet frequencies of some food were associated with hair PAEs concentrations.Egg and milk intake might be a protective factor of lower PAEs concentration.