密蒙花中的1个新的环烯醚萜苷类化合物

A new iridoid glycoside from Buddleja officinalis

目的研究马钱科醉鱼草属密蒙花Buddleja officinalis干燥花蕾及花序的化学成分。方法采用加热回流提取、溶剂萃取、多种柱色谱方法进行分离纯化,并运用NMR、MS等现代谱学技术进行化合物结构鉴定。结果从密蒙花水提取物中分离得到20个化合物,分别鉴定为6α-羟基-8β-羟甲基-1β,5α,6β,7β,9α-五氢-7(8)-环氧-2-oxaind-3-烯-1-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(1)、6-O-甲基梓醇(2)、梓醇(3)、蒙花苷(4)、芹菜素-7-O-芦丁糖苷(5)、木犀草素-7-O-芦丁糖苷(6)、密蒙花新苷(7)、芹菜素-7-O-半乳糖醛酸苷(8)、芹菜素-7,4′-O-葡萄糖醛酸苷(9)、芹菜素-7-O-α-鼠李糖基-(1→2)-β-葡萄糖醛酸苷(10)、腺嘌呤核苷(11)、鸟嘌呤核苷(12)、香草酸(13)、鸢尾番红花素M(14)、苦藏花素(15)、二氢红花菜豆酸-3′-O-β-D-葡萄糖苷(16)、二氢红花菜豆酸钠盐-3′-O-β-D-葡萄糖苷(17)、(E)-芥子酸-4-O-β-D-吡喃葡萄糖苷(18)、咖啡酸(19)、绿原酸(20)。结论化合物1为新的环烯醚萜苷类化合物,命名为6′-O-α-L-鼠李糖基梓醇,化合物9、10、15~18均为首次从醉鱼草属植物中分离得到,化合物3、8、11、12、19和20为首次从密蒙花中分离得到。

Objective To study the chemical constituents from water extract of the air-dried flower buds of Buddleja officinalis(Loganiaceae).Methods The compounds were isolated and purified by reflux-extraction,solvent extraction and column chromatography(CC),and their chemical structures were elucidated on the basis of 1 D-NMR,2 D-NMR,and MS data.Results Twenty compounds were isolated from the water extract of B.officinalis and identified as 6α-hydroxy-8β-hydroxymethyl-1β,5α,6β,7β,9α-pentahydro-7(8)-epoxy-2-oxaind-3-ene-1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(1),6-O-methylcatalpol(2),catalpol(3),linarin(4),apigenin-7-O-rutinoside(5),luteolin-7-O-rutinoside(6),neobudofficide(7),apigenin-7-O-galacturonide(8),apigenin-7,4′-di-O-glucuronide(9),apigenin-7-O-α-rhamnopyranosyl-(1→2)-β-glucuronide(10),adenosine(11),guanosine(12),vanillic acid(13),crocusatin M(14),picrocrocin(15),dihydrophaseic acid-3′-O-β-D-glucopyranoside(16),dihydrophaseic acid sodium salt-3′-O-β-D-glucopyranoside(17),(E)-sinapic acid-4-O-β-D-glucopyranoside(18),caffeic acid(19),and chlorogenic acid(20).Conclusion Compound 1 is a new iridoid glycoside,named 6′-O-α-L-rhamnopyranosyl-catalpol,and compounds 9,10,15—18 are isolated from Buddleja genus for the first time.Furthermore,3,8,11,12,19 and 20 are isolated from the flower buds of B.officinalis for the first time.