新型冠状病毒肺炎相关儿童多系统炎症综合征临床诊治研究进展

The progress of climical diagonsis and treatment in corona virus disease 2019 associated multisystem inflammatory syndrome in children

虽然目前儿童总体新型冠状病毒肺炎(corona virus disease 2019,COVID-19)感染率较低,病情相对轻微,罕见重症病例,病死率显著低于成人,但部分COVID-19可能诱发患儿细胞因子风暴,导致儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C)。MIS-C病情危重,进展迅速,但若早期明确诊断,及时正确干预,预后则良好。本文归纳了近期有关MIS-C性质、发病机制、流行病学、临床特征及诊治要点的文献,以供临床参考。

Although corona virus disease 2019(COVID-19)is relatively low in children,the condition of illness is relatively mild,and the rare severe cases,the case fatality rate is significantly lower than those in adults.However,some COVID-19 cases may induce cytokines storm in children,leading to multiple system inflammation syndrome in children(MIS-C).MIS-C is critically ill with rapid progress,but if early diagnosis and timely and correct intervention,the prognosis is good.This article summarized the recent literatures on the nature,pathogenesis,epidemiology,clinical features,diagnosis and treatment of MIS-C for clinical reference.