全球新型冠状病毒肺炎家庭续发率的Meta分析

Global household secondary attack rate of coronavirus disease 2019:a Meta-analysis

目的了解全球新型冠状病毒肺炎家庭续发率及其影响因素。方法截止到2020年12月28日,采用coronavirus/COVID/SARS-CoV-2 attack rate/secondary attack rate/household secondary attack rate/household contact/household transmission/familial cluster/close-contact transmission/person to person transmission为检索词,在PubMed、EMBASE和ScienceDirect等多个数据库进行检索。最终利用Meta分析方法对符合纳入标准的文献进行家庭续发率加权合并分析,并进行指示病例特征和家庭接融者特征的亚组分析。利用Newcastle-Ottawa量表对新型冠状病毒肺炎家庭续发率研究的文献进行质量评价,并进行敏感性分析。结果共55篇文献纳入分析,高质量研究文献9篇(16.4%),中等质量研究文献30篇(54.5%),低质量研究文献16篇(29.1%)。新型冠状病毒肺炎家庭续发率为18.4%(95%CI:16.4%-20.5%),其中,亲属关系的家庭接触者其续发率为18.9%(95%CI:14.6%-23.2%),同住关系的家庭接触者其续发率为18.4%(95%CI:15.9%~20.9%)0指示病例和家庭接触者的不同特征对家庭续发率有明显影响。结论全球不同国家新型冠状病毒感染的家庭续发率较高。在新型冠状病毒大流行的背景下,要采取强有力的措施控制家庭内感染,预防和控制家庭聚集性疫情的发生。

Objective To review the global household secondary altack rate of coronavirus disease 2019(COVID-19)and its influencing factors.Methods Relevant studies available before December 28,2020 were identified by search-ing PubMed,EMBASE,and ScienceDirect using the following keywords:coronavirus/COVID/SARS-CoV-2,attack rate/secondary attack rate/household secondary attack rate/household contact/household transmission/familial clusterclose-contact transmission/person to person transmission.The household secondary attack rate in the included litera-tures were ananlyzed by using meta-analysis.Subgroup analysis was conducted by the characteristics of index cases and household contacts.Newcastle-Ottawa Scale was used to evaluate the quality of the included literatures,and sensi tivity analysis was conducted.Results A total of 55 studies were included,including 9 high quality(16.4%),30 medi-um quality(54.5%)and 16 low quality literatures(29.1%).The household secondary attack rate of COVID-19 was 18.4%(95%CI:16.4%-20.5%),with 18.9%(95%CI:14.6%-23.2%)in family conlacts and 18.4%(95%CI:15.9%20.9%)in household contacts,respectively.The different characteristics of index cases and household contacts had sig.nificant influence on the household secondary attack rate of COVID-19.Conclusion Household secondary attack rate of COVID-19 was high worldwide.Under the background of COVID-19 pandemic,we should take strong measures to control the infection in the family,prevent and control the occurrence of family cluster of COVID-19 infection.