阿托伐他汀钙治疗老年脑动脉硬化的效果及对患者TC、TG、HDL-C、LDL-C水平的影响观察

Efficacy of atorvastatin calcium in the treatment of senile cerebral arteriosclerosis and its influence on the levels of TC,TG,HDL-C and LDL-C

目的分析阿托伐他汀钙治疗老年脑动脉硬化的效果及对患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平的影响。方法70例老年脑动脉硬化患者,随机分为对照组和观察组,各35例。对照组患者采取常规药物治疗,观察组在对照组基础上增加阿托伐他汀钙治疗。比较两组开始用药至血脂改善时间、住院时间,治疗前后TC、TG、HDL-C、LDL-C水平,治疗效果,不良反应发生情况。结果观察组开始用药至血脂改善时间、住院时间分别为(7.43±1.71)、(9.12±2.34)d,均短于对照组的(8.78±2.21)、(10.42±2.78)d,差异有统计学意义(P<0.05)。治疗后,观察组TC、TG、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率94.29%高于对照组的74.29%,差异有统计学意义(χ^(2)=5.285,P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0,P>0.05)。结论阿托伐他汀钙治疗老年脑动脉硬化的效果确切,可有效调节患者的血脂水平,提高治疗效果,且安全性高,无明显不良反应,值得推广。

Objective To analyze the efficacy of atorvastatin calcium in the treatment of senile cerebral arteriosclerosis and its influence on the levels of total cholesterol(TC),triglycerides(TG),highdensity lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C).Methods A total of 70 cases of senile cerebral arteriosclerosis were randomly divided into contrl group and observation group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with atorvastatin calcium based on the control group.The onset time,hospitalization time,levels of TC,TG,HDL-C and LDL-C before and after treatment,treatment effect and the occurrence of adverse reactions were compared between the two groups.Results The onset time and hospitalization time of the observation group were(7.43±1.71)and(9.12±2.34)d,which were all shorter than(8.78±2.21)and(10.42±2.78)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TC,TG and LDL-C of the observation group were lower than those of the control group,and HDL-C was higher than that of the control group.The difference was statistically significant(P<0.05).The total effective rate of treatment 94.29%of the observation group was higher than 74.29%of the control group,and the difference was statistically significant(χ^(2)=5.285,P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(χ^(2)=0,P>0.05).Conclusion Atorvastatin calcium has affirmative effect on the treatment of senile cerebral arteriosclerosis,which can effectively regulate the level of blood lipids in senile patients with cerebral arteriosclerosis and improve the therapeutic effect with high safety and no obvious side effects.It is worth popularizing and applying.