中国9个长寿地区65岁及以上人群氧化应激水平与高甘油三酯血症的关联研究

Association of blood oxidative stress level with hypertriglyceridemia in the elderly aged 65 years and older in 9 longevity areas of China

目的探讨我国长寿地区65岁及以上老年人氧化应激水平与高甘油三酯血症的关系。方法研究对象来源于2017-2018年“老年健康生物标志物队列研究”,最终将我国9个长寿地区2393名65岁及以上老年人群纳入研究。通过问卷调查和体格检测,收集调查对象的人口学特征、生活方式及健康状况等信息,同时采集调查对象的静脉血以检测丙二醛(MDA)、超氧化物歧化酶(SOD)及甘油三酯水平。采用限制性立方样条拟合多重线性回归模型分析MDA、SOD与甘油三酯的关联,采用广义线性混合效应模型分析氧化应激与高甘油三酯血症的关联。结果2393例调查对象年龄为(84.6±11.3)岁,最小65岁,最大112岁;男性1145名(47.9%);甘油三酯水平为(1.4±0.8)mmol/L,高甘油三酯血症检出率为9.99%(239名)。限制性立方样条拟合多重线性回归模型分析结果显示,MDA水平与甘油三酯水平呈线性关联;SOD水平与与甘油三酯水平呈非线性关联。广义线性混合效应模型分析结果显示,调整相关混杂因素后,MDA每升高1 nmol/ml,高甘油三酯血症检出风险增加[OR(95%CI)值为1.063(1.046,1.081)];SOD每升高1 U/ml,高甘油三酯血症检出风险降低[OR(95%CI)值分别为0.986(0.983,0.989)]。结论我国9个长寿地区65岁及以上老年人MDA和SOD水平与高甘油三酯血症发生风险有关联。

Objective To investigate the association of blood oxidative stress level with hypertriglyceridemia in the elderly aged 65 years and older in China.Methods A total of 2393 participants aged 65 years and older were recruited in 9 longevity areas from Heathy Aging and Biomarkers Cohort Study,during 2017 to 2018.Information on demographics characteristic,life style and health status were collected by questionnaire and physical examination,and venous blood was collected to detect the levels of blood oxidative stress and hypertriglyceridemia.The linear or non-linear association between oxidative stress and hypertriglyceridemia was described by restrictive cubic splines(RCS)fitting multiple linear regression model.The generalized linear mixed effect model was conducted to assess the association between oxidative stress and hypertriglyceridemia.Results A total of 2393 participants,mean age was 84.6 years,the youngest was 65 and the oldest was 112,the male was 47.9%(1145/2393),the triglyceride level was(1.4±0.8)mmol/L.The hypertriglyceridemia detection rate was 9.99%(239/2393).The results of multiple linear regression model with restrictive cubic spline fitting showed that MDA level was linear association with triglyceride level;SOD level was nonlinear association with triglyceride level.MDA level had significantly association with hypertriglyceridemia,and the corresponding OR value was 1.063(95%CI:1.046,1.081)with 1 nmol/ml increment of blood MDA;SOD level had significantly association with hypertriglyceridemia,and the corresponding OR value was 0.986(95%CI:0.983,0.989)with 1 U/ml increment of blood SOD.Conclusion Among the elderly aged 65 and older in 9 longevity areas in China,MDA and SOD levels were associated with the risk of hypertriglyceridemia.