中国9个长寿地区65岁及以上人群血砷水平与高尿酸血症的关联研究

Association of blood arsenic level with hyperuricemia among elderly aged 65 years and older in 9 longevity areas of China

目的分析65岁及以上人群血砷水平与高尿酸血症的关联。方法研究对象来自2017-2018年在我国9个长寿地区开展的“老年健康生物标志物队列研究”,共纳入2438名血砷和血尿酸数据完整的65岁及以上研究对象。通过问卷调查和体格检查,收集调查对象的人口学特征、生活方式及健康状况等信息;同时采集调查对象的静脉血以检测血砷、血尿酸等水平。根据血砷水平的三分位数将对象分为砷低水平组、砷中水平组和砷高水平组,采用logistic回归模型分析血砷水平和高尿酸血症的关联。结果2438名研究对象年龄为(84.57±11.41)岁,其中男性1172名(48.07%),≥80岁者1525名(62.55%),高尿酸血症的检出率为17.23%(420例)。砷低、中、高水平组的高尿酸血症检出率分别为11.77%、19.25%和20.62%(P<0.001)。多因素logistic回归模型分析结果显示,调整相关混杂因素后,与砷低水平组相比,砷中、高水平组高尿酸血症检出风险较高[OR(95%CI)值分别为1.57(1.12~2.23)和2.08(1.46~2.99)]。与女性相比,男性老年人血砷水平与高尿酸血症的关联更为显著(P_(交互)值<0.05)。结论中国9个长寿地区65岁及以上老年人群血砷水平与高尿酸血症的检出风险存在关联。

Objective To investigate the association of blood arsenic level with hyperuricemia among elderly aged 65 years and older.Methods Data was collected in 9 longevity areas from Heathy Aging and Biomarkers Cohort Study between 2017 and 2018.2438 participants aged 65 years and older with complete information on blood arsenic and uric acid were included in this study.Information including demographics characteristic,life style and health status was collected by questionnaire and physical examination.Meanwhile,venous blood was collected to detect the levels of blood arsenic and uric acid.Subjects were stratified into three groups(low,middle and high)by tertiles of blood arsenic level.Logistic regression models were used to analyze the association of blood arsenic level with hyperuricemia.Results The age of participants was(84.57±11.41)years,of which 1172(48.07%)were male and 1525(62.55%)were over 80 years old.The detection rate of hyperuricemia was 17.23%(420),and the detection rates of hyperuricemia were 11.77%,19.25%and 20.62%among participants with low,middle and high blood arsenic,respectively(P<0.001).After controlling confounding factors,compared with participants who had low blood arsenic,the ORs(95%CI)of hyperuricemia for the participants with middle and high blood arsenic were 1.57(1.12-2.23)and 2.08(1.46-2.99),respectively.Subgroups analysis showed that compared with female,the association between blood arsenic level and hyperuricemia was more obvious in males(P_(interaction)<0.05).Conclusion Blood arsenic level is associated with the risk for hyperuricemia among the elderly aged 65 years and older in 9 longevity areas in China.