新型冠状病毒与干扰素相互作用研究进展

Research progress in 2019-nCoV and interferon interaction

新型冠状病毒(2019-nCoV)是新型冠状病毒肺炎(COVID-19)的病原体,部分严重患者可能会出现呼吸衰竭甚至死亡,给全球公共卫生带来了巨大挑战。2019-nCoV编码的蛋白质不仅参与病毒增殖,而且在拮抗宿主固有免疫尤其是干扰素(interferon,IFN)应答中发挥重要作用。本文对调控宿主干扰素应答反应的2019-nCoV蛋白进行总结,对2019-nCoV和干扰素之间复杂的相互作用进行概述,以期为疾病防控提供理论依据。

Novel coronavirus(2019-nCoV)is the pathogen of COVID-19.Some severe cases may suffer from respiratory failure or even death,which poses a great challenge to global public health.2019-nCoV proteins not only participate in virus proliferation,but also play an important role in antagonizing host innate immune response,especially interferon response.In this paper,2019-nCoV proteins involved in regulating host interferon response and the complex interaction between 2019-nCoV and interferons were summarized,aiming to provide a theoretical reference for the prevention and control of COVID-19.