心房颤动患者轻度认知功能障碍的研究进展

Research progress of mild cognitive impairment in patients with atrial fibrillation

心房颤动可以通过炎症、低灌注、血栓栓塞等多重机制引起颅内病变并影响认知功能,增加轻度认知功能障碍(MCI)及痴呆的风险。MCI是认知功能下降过程中的早期阶段,是临床干预的关键时期,积极的多学科综合管理可延缓认知功能下降进程甚至一定程度改善认知功能,从而预防痴呆。心房颤动患者MCI的患病率居高不下,保护认知功能已逐渐成为心房颤动治疗领域的新话题。本文主要对心房颤动患者MCI的临床特征、相关危险因素及防治策略等进行综述。

Atrial fibrillation(AF)can cause intracranial pathological changes and increase the risk of the mild cognitive impairment(MCI)and dementia by multiple mechanism such as inflammation,low perfusion,thromboembolism.MCI is an early stage in the process of cognitive decline and is the key stage of clinical intervention.Active multidisciplinary managements can delay the decline of cognitive function and even improve cognitive function to a certain extent,so as to prevent dementia.The prevalence of MCI in patients with AF remains high,and the protection of cognitive function has gradually become a new topic in the field of AF treatment.This paper reviews the clinical features,related risk factors and prevention and treatment strategies of MCI in AF patients.