持续性有机污染物暴露与胰岛素抵抗的关联及可能机制的研究进展

Research progress on the association and possible mechanism of persistent organic pollutants exposure and insulin resistance

持续性有机污染物(POPs)作为一类理化性质稳定、难降解、高脂溶性、疏水性、远距离传输、高蓄积性的环境污染物,不仅造成环境污染,而且多年来在人类和生物体的脂肪组织内形成蓄积。各国许多大规模流行病学研究表明,POPs与2型糖尿病和胰岛素抵抗的发生有着密切的相关性,然而,对于POPs与胰岛素抵抗的病理机制并未明确。在本文中,我们回顾了有关POPs暴露与胰岛素抵抗之间的关联以及可能的分子机制的相关文献,最终表明POPs暴露会增加发生胰岛素抵抗及2型糖尿病的风险,可能与POPs导致氧化应激、线粒体功能障碍、炎症、干扰胰岛素信号传导等有关。

Persistent organic pollutants(POPs),as a class of environmental pollutants with stable physical and chemical properties,difficult to degrade,high lipid solubility,hydrophobicity,long-distance transport,and high accumulation,not only cause environmental pollution,but also form accumulation in human and biological adipose tissues over the years.Many large-scale epidemiological studies in various countries have shown that POPs are closely related to the occurrence of type 2 diabetes and insulin resistance,however,the pathological mechanism between POPs and insulin resistance is not clear.This article reviews the related literatures on the association between POPs exposure and insulin resistance and possible molecular mechanisms,and finally show that POPs exposure will increase the risk of insulin resistance and type 2 diabetes,which may be associated with POPs leading to oxidative stress,mitochondrial function disorders,inflammation,and interference with insulin signaling transmission.