亲电环化合成异喹啉的研究进展

Progress on Synthesis Isoquinoline Derivatives by Electrophilic Cyclization

综述了以2-炔基苄亚胺、2-炔基苄基叠氮、2-炔基苯甲醛肟及其2-炔基苯甲醛腙为底物,在亲电试剂催化下合成多取代异喹啉及其衍生物,对部分反应的机理进行了讨论,并对比讨论了这四种底物合成方法的优缺点。2-炔基苯甲醛肟及2-炔基苯甲醛腙的衍生物与亲电试剂反应不仅可以生成异喹啉骨架的叶立德化合物,而且这些叶立德可以一步与活性双键或三键化合物通过[3+2]环加成反应生成结构复杂的多取代的异喹啉衍生物。

The synthesis of substituted isoquinolines and its derivatives with 2-alkynylbenzylimine,2-alkynylbenzylazide,2-alkynylbenzaldehyde oxime and its 2-alkynylbenzaldehyde hydrazone as substrates were reviewed,and the mechanism of some reactions were also discussed.The advantages and disadvantages of these four methods were compared.The reaction of 2-alkynylbenzaldehyde oxime and 2-alkynylbenzaldehyde hydrazone derivatives with electrophilic reagents can not only produce isoquinoline skeleton yields,but also produce complex multisubstituted isoquinoline derivatives by[3+2]cycloaddition reaction with active double bond or triple bond compounds.