头颈部鳞癌预后相关肿瘤标志物的研究现状

The research status of tumor markers related to prognosis of head and neck squamous cell carcinoma

近年来,头颈部鳞癌的治疗已经有了很大的进展,患者通过手术治疗、放疗或化疗,疾病控制和患者生活质量均可得到较大改善,但是总体生存率依旧很低,主要原因是肿瘤的复发和转移。对于头颈部鳞癌患者肿瘤复发的监测,临床医生需要借助某些手段来协助发现肿瘤的局部复发及转移,从而有助于及时采取治疗。因此,寻找一个确切的肿瘤标志物来辅助临床诊断、判断患者对治疗的反应,以及及早发现肿瘤的局部复发和转移已经成为一个需要被关注的问题。该篇文章主要综述的是目前研究认为对头颈部鳞癌可能有预后作用的肿瘤标志物。

In recent years,great progress has been made in the treatment of head and neck squamous cell carcinoma.Disease control and the quality of life of patients can be greatly improved through surgery,radiotherapy or chemotherapy.But the overall survival rate is still very low,mainly because of the recurrence and distant metastasis.If the clinicians have some tools for the detection of local recurrence and metastasis,the patients will accept the treatments at the early stage.However,for the patients with head and neck squamous cell carcinoma,it has become a major concern to find a reliable tumor marker to assist clinical diagnosis,judge patients’ response of treatment and early detection of local recurrence.This review mainly describes tumor markers that are likely to be prognostic for head and neck squamous cell carcinoma.