血清白细胞介素细胞因子联合IgE在变应性鼻炎中的表达及临床诊断价值分析

Expression of serum interleukin cytokines combined with IgE in allergic rhinitis and its clinical diagnostic value

目的分析血清白介素细胞因子联合IgE在变应性鼻炎(AR)中的表达及临床诊断价值。方法选择2017年1月-2018年10月于本院接受诊治的135例变应性鼻炎患者作为研究组,并根据患者的病情严重程度分成轻度组73例、中重度组62例;另将同期于本院行健康体检的60例正常人员作为健康对照组。对2组人员的血清IL-4、IL-9、IgE表达水平进行测定,分析血清白介素细胞因子和IgE的相关性。结果相较于对照组,研究组患者的血清IL-4、IL-9、IL-17、IgE表达水平均增高,差异有统计学意义(P <0.05);中重度组血清IL-4、IL-9、IL-17、IgE指标高于轻度组,差异有统计学意义(P <0.05);Pearson相关性检验结果显示,研究组血清IgE与IL-4、IL-17显示为正相关(r值分别为0.577、0.583,P值均<0.05)。结论血清IL-4、IL-9、IL-17及IgE于变应性鼻炎患者的血清中表达显著增高,且血清IgE和IL-4、IL-17显示为正相关,提示检测血清白介素细胞因子、IgE表达能为临床诊断变应性鼻炎、判定病情严重程度提供参考。

Objective To analyze the expression and clinical diagnostic value of serum interleukin cytokines combined with IgE in allergic rhinitis(AR). Methods A total of 135 patients with allergic rhinitis who were treated in our hospital from January 2017 to October 2018 were selected as the study group. According to the severity of the patient’s condition,73 patients were classified into mild group and 62 cases were moderately severe. In addition,60 cases of normal people who performed health checkups in this hospital were used as healthy controls. The serum levels of IL-4,IL-9 and IgE were measured in the two groups,and the correlation between serum interleukin cytokines and IgE was analyzed. Results Compared with the control group,the levels of serum IL-4,IL-9,IL-17 and IgE in the study group increased(P < 0. 05). The levels of serum IL-4,IL-9,IL-17 and IgE in the moderate-to-severe group were higher than those in the mild group(P < 0. 05). Pearson correlation analysis showed that serum IgE and IL-4 and IL-17 were positively correlated in the study group(r = 0. 577,0. 583,P <0. 05). Conclusion The serum levels of IL-4,IL-9,IL-17 and IgE are significantly increased in serum of patients with allergic rhinitis,and serum IgE and IL-4 and IL-17 are positively correlated,suggesting the detection of serum interleukin cytokines. IgE expression can provide a reference for the clinical diagnosis of allergic rhinitis and the severity of the disease.