摘要
目的比较艾司西酞普兰与帕罗西汀治疗老年性抑郁症的效果。方法将2017年2月1日至2019年2月1日收治的98例老年性抑郁症患者按随机数字表法分为A组和B组,每组49例。A组患者予以艾司西酞普兰治疗,B组患者予以帕罗西汀治疗,比较两组的治疗效果。结果两组的治疗总有效率比较,差异无统计学意义(P>0.05)。治疗2周时,A组的HAMD、PSQI评分均低于B组,差异具有统计学意义(P<0.05)。治疗8周时,A组的S100B蛋白、Cro、Hcy水平均低于B组,差异具有统计学意义(P<0.05)。A组的不良反应率总发生率低于B组,差异具有统计学意义(P<0.05)。结论艾司西酞普兰与帕罗西汀治疗老年性抑郁症的效果相当,但与帕罗西汀比较,艾司西酞普兰起效更快,安全性更高,且在改善神经功能方面更有优势。
Objective To compare the effects of escitalopram and paroxetine in the treatment of senile depression.Methods A total of 98 patients with senile depression enrolled from February 1,2017 to February 1,2019 were randomly divided into group A and group B,with 49 cases in each group.The group A was treated with escitalopram,and the group B was treated with paroxetine.The therapeutic effects of the two groups were compared.Results There was no significant difference in the total effective rate of treatment between the two groups(P>0.05).At 2 weeks of treatment,the HAMD and PSQI scores in the group A were lower than those in the group B,and the differences were statistically significant(P<0.05).At 8 weeks of treatment,the levels of S100B protein,Cro and Hcy in the group A were lower than those in the group B,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the group A was lower than that in the group B,and the differences were statistically significant(P<0.05).Conclusion Escitalopram and paroxetine have the same effect in the treatment of senile depression,but compared with paroxetine,escitalopram has faster effect,higher safety,and more advantages in improving neurological function.
作者
宋金鹏
葛婷
孙维
张帆
SONG Jinpeng;GE Ting;SUN Wei;ZHANG Fan(Baoji Rehabilitation Hospital,Baoji 721001;No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)
出处
《临床医学研究与实践》
2021年第6期46-48,共3页
Clinical Research and Practice