艾司西酞普兰与帕罗西汀治疗老年性抑郁症的效果比较

Comparison of the effects of escitalopram and paroxetine in the treatment of senile depression

目的比较艾司西酞普兰与帕罗西汀治疗老年性抑郁症的效果。方法将2017年2月1日至2019年2月1日收治的98例老年性抑郁症患者按随机数字表法分为A组和B组,每组49例。A组患者予以艾司西酞普兰治疗,B组患者予以帕罗西汀治疗,比较两组的治疗效果。结果两组的治疗总有效率比较,差异无统计学意义(P>0.05)。治疗2周时,A组的HAMD、PSQI评分均低于B组,差异具有统计学意义(P<0.05)。治疗8周时,A组的S100B蛋白、Cro、Hcy水平均低于B组,差异具有统计学意义(P<0.05)。A组的不良反应率总发生率低于B组,差异具有统计学意义(P<0.05)。结论艾司西酞普兰与帕罗西汀治疗老年性抑郁症的效果相当,但与帕罗西汀比较,艾司西酞普兰起效更快,安全性更高,且在改善神经功能方面更有优势。

Objective To compare the effects of escitalopram and paroxetine in the treatment of senile depression.Methods A total of 98 patients with senile depression enrolled from February 1,2017 to February 1,2019 were randomly divided into group A and group B,with 49 cases in each group.The group A was treated with escitalopram,and the group B was treated with paroxetine.The therapeutic effects of the two groups were compared.Results There was no significant difference in the total effective rate of treatment between the two groups(P>0.05).At 2 weeks of treatment,the HAMD and PSQI scores in the group A were lower than those in the group B,and the differences were statistically significant(P<0.05).At 8 weeks of treatment,the levels of S100B protein,Cro and Hcy in the group A were lower than those in the group B,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the group A was lower than that in the group B,and the differences were statistically significant(P<0.05).Conclusion Escitalopram and paroxetine have the same effect in the treatment of senile depression,but compared with paroxetine,escitalopram has faster effect,higher safety,and more advantages in improving neurological function.