免疫固定电泳在多发性骨髓瘤辅助诊断中的临床价值

Clinical value of immunofixation electrophoresis in auxiliary diagnosis of multiple myeloma

目的探讨血清免疫固定电泳在多发性骨髓瘤(MM)的辅助诊断与治疗中的临床价值。方法以2017年1月至2019年10月就诊于新疆维吾尔自治区人民医院的74例MM患者作为研究对象,分别取血清进行免疫固定电泳与蛋白电泳,收集两种电泳方法的M蛋白检测结果并进行统计学处理。结果74例MM患者中,血清蛋白电泳检出M蛋白51例(68.9%),免疫固定电泳检出72例(97.3%),其中IgG型47例(63.5%),IgA型15例(20.3%),IgM型4例(5.4%),轻链型6例(8.1%),血清免疫固定电泳M蛋白检出率高于血清蛋白电泳(P<0.05)。结论血清免疫固定电泳能够快速、便捷而又准确地对MM进行诊断及分型,具有重要的临床价值,应将其作为MM常规的检测方法之一。

Objective To investigate the clinical value of serum immunofixation electrophoresis in the auxiliary diagnosis and treatment of multiple myeloma(MM).Methods A total of 74 patients with MM who were admitted to the People′s Hospital of Xinjiang Uygur Autonomous region from January 2017 to October 2019 were selected as the research subjects,their serum samples were collected for immunofixation electrophoresis and protein electrophoresis respectively,and the M protein detection results of the two electrophoresis methods were collected and statistically analyzed.Results Among 74 patients with MM,51 cases(68.9%)were detected M protein by serum protein electrophoresis,72 cases(97.3%)were detected M protein by immunofixation electrophoresis,including 47 cases(63.5%)of IgG type,15 cases(20.3%)of IgA type,4 cases(5.4%)of IgM type and 6 cases(8.1%)of light chain type.The detection rate of M protein in serum immunofixation electrophoresis was higher than that of serum protein electrophoresis(P<0.05).Conclusion Serum immunofixation electrophoresis can quickly,conveniently and accurately diagnose and classify MM,and has important clinical value,it should be used as one of the routine detection methods for MM.