穴位敷贴辅助治疗对癌性疼痛患者血清疼痛介质的影响及疗效

Effect and curative effect of acupoint application adjuvant treatment on serum pain mediator in patients with cancer pain

目的探讨穴位敷贴辅助治疗对癌性疼痛患者血清疼痛介质的影响及疗效。方法选取2017年6月至2019年6月我院就诊的癌性疼痛患者80例,随机分为观察组和对照组。对照组患者予以盐酸羟考酮缓释片治疗,观察组患者在此治疗基础上加用穴位敷贴,两组患者均连用4周。观察两组患者治疗前后血清疼痛介质[前列腺素E2(PGE2)、P物质(P)和β-内啡肽(β-EP)]水平差异,并比较其临床效果。结果治疗4周后,两组患者血清PGE2、P和β-EP水平均较治疗前明显下降,差异有统计学意义(P<0.05或P<0.01),且观察组患者下降幅度较对照组更明显,差异有统计学意义(P<0.05);治疗4周后,观察组患者疼痛缓解率高于对照组,差异有统计学意义(χ2=4.113,P<0.05)。结论穴位敷贴辅助治疗癌性疼痛患者能有效降低血清疼痛介质PGE2、P和β-EP水平,提高治疗效果。

Objective To explore the effect and curative effect of acupoint application adjuvant therapy on serum pain mediators in patients with cancerous pain.Methods Eighty patients with cancer pain in our hospital from June 2017 to June 2019 were selected and randomly divided into observation group and control group.The patients in the control group were treated with oxycodone hydrochloride sustained-release tablets.The patients in the observation group were treated with acupoint application on the basis of this treatment.The two groups were used for 4 weeks.The difference in the levels of serum pain mediators(prostaglandin E2[PGE2],substance P[P]andβ-endorphin[β-EP])before and after treatment between the two groups was observed.Their clinical effects were compared.Results After 4 weeks of treatment,the serum PGE2,P andβ-EP levels of the two groups decreased significantly compared with those before treatment,and the difference was statistically significant(P<0.05 or P<0.01).The decrease of the observation group was more obvious than that of the control group,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the pain relief rate of the observation group was higher than that of the control group,and the difference was statistically significant(χ2=4.113,P<0.05).Conclusion Acupoint application in adjuvant treatment of cancer pain patients can effectively reduce the levels of serum pain mediators PGE2,P andβ-EP and improve the treatment effect.