成人胸腔感染病原菌分布及耐药性分析

Analysis of microbial distribution and drug resistance in adult pleural infection

目的分析胸腔感染的病原菌分布及耐药情况。方法回顾性分析2015年1月至2020年2月于我院住院的胸腔积液患者的临床资料和病原菌培养结果。结果纳入120例胸腔积液病原菌培养阳性的患者,共分离出病原菌143株,包括革兰氏阳性菌62株(43.36%),革兰氏阴性菌71株(49.65%),真菌10株(6.99%)。主要革兰氏阳性菌普遍对万古霉素、利奈唑胺敏感。主要革兰氏阴性菌对替加环素敏感性好,多重耐药鲍曼不动杆菌阳性率为88.89%(16株/18株),且基本对碳青霉烯类耐药。结论我院胸腔感染以屎肠球菌、鲍曼不动杆菌为主。

Objective To investigate the distribution and drug resistance of pathogens in adult pleural infection. Methods We retrospectively reviewed the clinical data and pleural effusion culture results of all the patients with pleural infection who were admitted to Shengjing Hospital between January 2015 and February 2020. Results A total of 143 strains of pathogenic bacteria were isolated from 120 patients with pleural infection, including 62 strains of gram-positive bacteria(43.36%), 71 strains of gram-negative bacteria(49.65%) and 10 strains of fungus(6.99%).The main gram-positive bacterias were generally sensitive to vancomycin and linezolid. The main gram-negative bacterias were sensitive to tigecycline. The positive rate of multidrug-resistant Acinetobacter baumannii was 88.89%(16 strains/18 strains), and it was basically resistant to carbapenems. Conclusion Enterococcus faecium and Acinetobacter baumannii were the main causes of pleural infection in our hospital.