摘要
近年来PPAR-γ与动脉粥样硬化的是研究的重点,基于PPAR-γ基础上治疗动脉粥样硬化的相关研究更是大家关注的重点,PPAR-γ可以在多方面调控动脉粥样硬化,比如控制巨噬细胞脂质的内流,对抗动脉粥样硬化的炎症,调节炎症因子,介导血管平滑肌细胞的增值与迁徙等都是对抗动脉粥样硬化的方式。同时PPAR-γ与中医药的结合也为动脉粥样硬化患者带来了新的福音,不管是从复方汤剂还是中药单体都被发现其在PPAR-γ基础上的应用。本文将对PPAR-γ对抗动脉粥样硬化的作用,目前已在临床上进行的相关应用,以及在中医药学方面的应用进行相关综述。
In recent years, PPAR-γ and atherosclerosis have been the hot spots of research, and the research on the treatment of atherosclerosis based on PPAR-γ has caught the attention of scholars in this field. PPAR-γ can regulate atherosclerosis from many aspects, such as controlling the influx of lipids in macrophages, fighting the inflammation of atherosclerosis, and regulating inflammatory factors. Mediating the proliferation and migration of vascular smooth muscle cells is a way to combat atherosclerosis. At the same time, the combination of PPAR-γ and traditional Chinese medicine(TCM) approaches have also brought a new choice of treatment to patients with atherosclerosis. Whether compound decoction or monomer of medicinals has already been used in clinical practice based on PPAR-γ. This article reviewed the effects of PPAR-γ on atherosclerosis, its clinical application, and its application in TCM.
作者
李永林
顾问
尚莎莎
王贺
司春婴
关怀敏
陈玉善
Li Yonglin;Gu Wen;Shang Shasha;Wang He;Si Chunying;Guan Huaimin;Chen Yushan(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第12期4120-4125,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省中医管理局中医药科学研究专项课题(2018JDZX107):基于中医辨证指导下的ACS患者PCI术后综合干预临床光随访研究,负责人:陈玉善
河南省中医管理局中医药科学研究专项课题(2019ZY1004):化痰活血解毒优化方对ACS合并糖尿病患者PCI术后冠脉微循环的影响,负责人:陈玉善。
