荧光显像技术在消化外科中的应用进展

Fluorescence guidance in digestive surgery

近红外荧光显像技术可运用特殊分子的荧光特性增强显示人体重要解剖结构和组织血流灌注。笔者总结荧光显像技术原理、常用荧光分子特性和荧光显像设备特点,探讨荧光显像技术在胃食管外科、肝胆外科、结直肠外科及腹膜恶性肿瘤等外科实践中的应用价值。笔者认为:通过特异性抗体偶联荧光分子探针检出肿瘤转移灶是荧光显像技术应用于消化外科的未来发展方向。

Near infrared fluorescence capitalizes on the unique features of fluorophores by highlighting critical structures and allowing surgeons to assess vascular perfusion of native tissues.In this review,the authors discuss the physics of fluorescence,characteristics of commonly used fluorophores,and features of approved devices for use in surgery.The authors discuss supporting data and reports of fluorescence guidance in assessment and planning for colorectal and gastroesophageal anastomosis,identification of liver tumors,delineation of biliary anatomy during cholecystectomy,and localization of ureters.Future directions for the use of fluorescence guidance in gastrointestinal surgery include antibody-conjugated fluorophores to detect foci of tumor metastasis.