静止期炎性肠病患者粪便微生物群和TNF-α及IL-6与疲劳感的相关性

Correlation of faecal microbiota,TNF-αand IL-6 with fatigue in patients with quiescent inflammatory bowel disease

目的探讨静止期炎性肠病患者粪便微生物群和TNF-α及IL-6与疲劳感的相关性。方法选取2018年3月-2020年3月于本院消化内科就诊的80例静止期炎症性肠病(IBD)患者为研究组,72例活动期IBD患者为参照组,另选同期64例健康体检者为健康组,探讨静止期IBD患者与活动期及健康组受检者粪便生物群、TNF-α及IL-6变化及其与疲劳感的相关性。结果研究组与参照组和健康组对比,肠球菌、大肠杆菌、粪肠球菌及双歧杆菌数值差异均有统计学意义(P<0.05)。研究组患者TNF-α、IL-6水平与参照组患者及健康组受检者对比,差异有统计学意义(P均<0.05)。研究组患者躯体疲劳、脑力疲劳及总体疲劳得分均明显低于参照组患者(P<0.05);研究组患者各项疲劳得分与健康组对比,差异有统计学意义(P<0.05)。研究组患者静止期肠球菌、大肠杆菌、粪肠球菌、TNF-α及IL-6水平与疲劳呈正相关(P<0.05),而双歧杆菌与患者疲劳呈负相关(P<0.05)。结论炎症性肠病患者静止期TNF-α及IL-6指标及粪便生物群有所改善,而疲劳后检测数值的变化具有临床应用价值。

Objective To investigate the relationship between facal microbiota,TNF-α,IL-6 and fatigue in patients with static inflammatory bowel disease.Methods The 80 patients with static inflammatory bowel disease(IBD)who were in the Gastroenterology Department of our hospital from March 2018 to March 2020 were selected as the study group,and 72 patients with active inflammatory bowel disease IBD were selected as the reference group.In addiction,another 64 healthy subjects during the same period were selected.The changes of fecal biota,TNF-αand IL-6 in the patients with static IBD and active,and their correlation with fatigue were investigated.Results Compared with the control group and the healthy group,the Enterococcus,Escherichia coli,Enterococcus faecalis and Bifidobacterium in the study group were significantly better than those in the control group(P<0.05),and there were significant differences between the study group and the healthy group.The levels of TNF-αand IL-6 in the study group were significantly different from those in the control group and healthy group(P<0.05).The scores of physical fatigue,mental fatigue and overall fatigue of the study group were significantly lower than those of the reference group,which increased with the worsening of the disease(P<0.05),and the difference between the fatigue scores of the study group and the health group was statistically significant(P<0.05).The levels of stationary Enterococcus,Escherichia coli,Enterococcus faecalis,TNF-αand IL-6 in the study group were positively correlated with fatigue(P<0.05),while Bifidobacterium was negatively correlated with fatigue(P<0.05).Conclusion In patients with inflammatory bowel disease,the serum indicators of TNF-αand IL-6 and the fecal biota in the quiescent phase have been improved,and the changes in the detection values after fatigue have clinical application value.