桂枝茯苓丸加减治疗子宫腺肌病的Meta分析

Guizhi Fuling Formula for Adenomyosis:A Meta-analysis of Randomized Controlled Trials

目的对以桂枝茯苓丸为主方的方剂及中成药治疗子宫腺肌病的有效性及安全性进行评估。方法检索中国期刊全文数据库(CNKI)、万方数字化期刊、维普中文科技期刊、中国生物医学文献服务系统、Pub Med、EMbase、Cochrane Library数据库,整理所有桂枝茯苓丸加减治疗子宫腺肌病的随机对照试验进行Meta分析。结果纳入11篇文献共822例患者,应用桂枝茯苓丸为主方的汤剂及桂枝茯苓丸中成药或联合西医常规疗法的VAS痛经评分、血清癌胚抗原(CA125)、血清血管内皮生长因子(VEGF)、中医证候评分均低于单用西医常规疗法,应用桂枝茯苓丸中成药或联合西医常规疗法的子宫体积小于单用西医常规疗法,应用桂枝茯苓丸为主方的汤剂的不良反应发生率低于单用西医常规疗法。结论桂枝茯苓丸加减或联合西医常规疗法治疗子宫腺肌病在降低VAS痛经评分、血清CA125、血清VEGF、中医证候评分方面优于单用西医常规疗法。

Objective Evaluate the effectiveness and safety of Guizhi Fuling formula in the treatment of adenomyosis.Methods Search the full-text databases including CNKI,Wanfang Data,VIP database,Sino Med,Pub Med,Embase and Cochrane Library databases.Collate all randomized controlled trials of Guizhi Fuling formula in treating adenomyosis to conduct a Meta-analysis.Results A total of 822 patients were included in 11 literatures.The VAS dysmenorrhea score,serum carcinoembryonic antigen(CA125),serum vascular endothelium were used as the main decoction of Guizhi Fuling Pills and Chinese patent medicine of Guizhi Fuling Pills or combined with conventional Western medicine Growth factor(VEGF)and TCM syndrome scores are lower than those of traditional Western medicine alone.The uterus volume of using Guizhi Fuling Pills or combined with Western medicine conventional therapies is smaller than that of using Guizhi Fuling Pills as the main prescription.The incidence of adverse reactions of decoction is lower than that of conventional western medicine.Conclusion The addition or subtraction of Guizhi Fuling Pills or the combination of conventional Western medicine therapy is better than conventional Western medicine alone in reducing VAS dysmenorrhea score,serum CA125,serum VEGF and TCM syndrome score.