外泌体在免疫介导性眼病中的研究进展

Recent advances of exosomes in immune-mediated eye diseases

免疫介导性眼病(immune-mediated eye diseases,IMED)是一类与免疫高度相关眼病的统称,主要包括甲状腺相关眼病、自身免疫性葡萄膜炎及Sjogren综合征等,其病理生理机制复杂、临床治疗效果欠佳,严重威胁着患者的视力健康。外泌体作为一种由细胞分泌的脂质双分子层囊泡,在细胞间通讯和免疫调节等方面起着重要的作用。诸多研究表明,外泌体不仅参与了IMED的发生与发展,某些细胞(如间充质干细胞)来源的外泌体还可用于IMED的治疗。本文拟对外泌体在IMED中的研究进展作一综述。

Immune-mediated eye diseases(IMED)represent a kind of autoimmune eye diseases,such as thyroid-associated ophthalmopathy,autoimmune uveitis and Sj gren syndromes.Owning to its complicated pathophysiological mechanisms,the efficacies of current therapeutic strategies for IMED are unsatisfactory,which may ultimately result in severe visual impairment.Exosomes are lipid bilayer vesicles secreted by cells that play an important role in cell-to-cell communication and immune regulation.Recent studies have shown that exosomes secreted by cells under pathological conditions are closely associated with the development and progression of IMED,and the exosomes derived from certain cells(such as mesenchymal stem cells)are deemed as promising therapy for IMED.Hence,we review the recent advances of exosomes in IMED.