近视儿童黄斑中心凹下脉络膜厚度的变化特征及影响因素

Variation characteristics and influencing factors of choroidal thickness of subfoveal fovea in children with myopia

目的:研究近视儿童黄斑中心凹下脉络膜厚度(SFCT)随时间变化的特征及其相关影响因素。方法:纳入2018-07/2018-09在南昌大学附属眼科医院就诊的6~15岁近视儿童60例60眼,分别在基线及随访6mo时测量眼压、眼轴长度、等效球镜度及SFCT,分析上述眼部参数的变化情况及SFCT的相关影响因素。结果:与基线时相比,随访6mo,近视儿童SFCT平均减少8±14μm(P<0.001),眼轴长度平均增加0.15±0.16mm(P<0.001),等效球镜度平均增加-0.34±0.33D(P<0.001),且SFCT变化值与眼轴长度、等效球镜度变化值存在显著相关性(r s=-0.701、0.633,均P<0.001),表明较快的眼轴增长和近视度数增加与更多的络膜厚度变薄有关。多元线性回归分析显示眼轴长度是SFCT的影响因素(P=0.001)。结论:近视儿童SFCT随着时间变薄,眼轴长度与SFCT呈负相关,且眼轴增长较快和近视度数增加较多的儿童通常也伴随着更多的SFCT变薄。

AIM:To study the characteristics and related influencing factors of subfoveal choroidal thickness(SFCT)changing with time in children with myopia.METHODS:Totally 60 eyes of 60 children with myopia aged 6-15 years old who were admitted to the Eye Hospital of Nanchang University from July 2018 to September 2018 were included.IOP,axial length,equivalent spherical degree and SFCT were measured at baseline and 6mo of follow-up,respectively.Analyze the changes of the above-mentioned eye parameters and related influencing factors of SFCT.RESULTS:Compared with baseline,follow-up for 6mo,myopic children’s SFCT decreased by 8±14μm(P<0.001),the axial length increased by 0.15±0.16mm(P<0.001),and the equivalent spherical degree increased by-0.34±0.33D(P<0.001),and there is a significant correlation between the SFCT change value and the axial length and equivalent spherical power change value(r s=-0.701,0.633,both P<0.001),indicating faster axial growth and myopia increasing is related to more thinning of the membrane thickness.Multiple linear regression analysis shows that SFCT is significantly correlated with axial length(P=0.001).CONCLUSION:The SFCT of myopic children becomes thinner over time,and the axial length is negatively correlated with SFCT,and children with faster axial growing and greater myopia increasing are usually accompanied by more SFCT thinning.