蛛网膜下腔出血患者并发下肢深静脉血栓的危险因素分析

Analysis of Risk Factors of Lower Extremity Deep Venous Thrombosis in Patients with Subarachnoid Hemorrhage

目的分析蛛网膜下腔出血(subarachnoid hemorrhage,SAH)患者并发下肢深静脉血栓(deep venous thrombosis,DVT)的危险因素,为DVT的预防和治疗提供临床指导。方法连续收集2017年5-12月于首都医科大学附属北京天坛医院神经内科收治的SAH患者的临床资料,根据患者住院期间是否发生DVT分为DVT组和无DVT组,收集患者年龄、性别、用药史、实验室检查、卒中危险因素及Hunt-Hess分级和世界神经外科联盟评分等资料,采用单因素及多因素logistic回归分析SAH后下肢DVT的危险因素。结果共纳入328例SAH患者,其中26例(7.9%)住院期间出现DVT。多因素分析结果显示,年龄增长(OR 1.051,95%CI 1.012~1.091,P=0.0097)和血小板计数升高(OR 1.008,95%CI 1.000~1.015,P=0.0493)是SAH患者住院期间发生DVT的独立危险因素。结论年龄增长和血小板计数升高是SAH患者住院期间发生DVT的独立危险因素。

Objective To analyze the risk factors for the lower extremity deep venous thrombosis(DVT)in patients with subarachnoid hemorrhage(SAH),and to provide clinical guidance for the prevention and treatment of DVT after SAH.Methods Data of SAH patients from Department of Neurology of Beijing Tiantan Hospital,Capital Medical University between May 2017 and December 2017 were retrospectively analyzed.All the patients were divided into two groups based on whether or not DVT occurred.Univariate and multivariate logistic regression model were used to analyze the risk factor for DVT after SAH.Results A total of 328 SAH patients were included,26(7.9%)of whom developed DVT during the hospitalization.Logistic regression analysis showed elder age(OR 1.051,95%CI 1.012-1.091,P=0.0097)and increased platelet count(OR 1.008,95%CI 1.000-1.015,P=0.0493)were independent risk factors for DVT in SAH patients.Conclusions Elder age and increased platelet count are independent risk factors for lower extremity DVT after SAH.