环状RNA的功能及其在结直肠癌中的研究进展

The function of circRNAs and its research progress in colorectal cancer

环状RNAs(circRNAs)是一种具有共价闭合环状的长链非编码RNA。circRNAs广泛存在于真核细胞并且结构稳定。circRNAs可作为微小RNAs(miRNAs)的分子海绵参与基因转录后调控,也可与多种蛋白相互作用,调控基因转录及蛋白翻译等。越来越多的研究表明,circRNA与结直肠癌的发生、发展密切相关,有望为结直肠癌的诊断和治疗提供新的分子标志物和靶点。本文从circRNAs的形成、生物学功能以及在结直肠癌疾病中的研究进展等方面进行简要综述,以期为结直肠癌早期诊断和治疗提供新靶点。

Circular RNAs(circRNAs)are one of long non-coding RNAs with covalently closed loops.CircRNAs are widely found in eukaryotic cells and have stable structure.CircRNAs can be used as a molecular sponge of microRNAs(miRNAs)to participate in gene post-transcriptional regulation,and can also interact with a variety of proteins to regulate gene transcription and protein translation.Accumulating studies have shown that circRNAs are closely related to the occurrence and development of colorectal cancer,and is expected to provide new molecular markers and targets for the diagnosis and treatment of colorectal cancer.In this review,we briefly summarized the formation,biological function and research progress of circRNAs in colorectal cancer and aimed at providing a new target for early diagnosis and treatment of colorectal cancer.